Analysis strategies for adaptive designs with multiple endpoints.


Journal Article

The problem of analysis strategies for adaptive designs with multiple endpoints is considered. We first provide a review of the commonly used methods for addressing the issue of multiplicity in classical designs, followed by the gatekeeper procedure and the fractal gatekeeper procedure. The latter will be applied to address the issue of multiplicity in adaptive trials with multiple endpoints based on the invariance property of the test statistic employed. Practical examples are presented to illustrate the proposed fractal gatekeeper method when analyzing data obtained from an adaptive trial with multiple endpoints.

Full Text

Duke Authors

Cited Authors

  • Chang, M; Chow, S-C

Published Date

  • 2007

Published In

Volume / Issue

  • 17 / 6

Start / End Page

  • 1189 - 1200

PubMed ID

  • 18027225

Pubmed Central ID

  • 18027225

International Standard Serial Number (ISSN)

  • 1054-3406

Digital Object Identifier (DOI)

  • 10.1080/10543400701645348


  • eng

Conference Location

  • England