Statistical issues in quality-of-life assessment.


Journal Article

In recent years, the assessment of drug effects on quality of life (QOL) has become very popular in clinical trials. QOL assessment quantifies the ability of a person to function normally in society. It may be used to distinguish between therapies that appear to be equally efficacious and equally safe. QOL is usually assessed by a QOL instrument, which consists of a number of questions. A QOL instrument is a very subjective tool that usually has a large variation. To ensure the accuracy and reliability of QOL assessment in clinical trials, the adopted QOL instrument should be validated. Some statistical tests are proposed for validation of a QOL instrument in terms of validity, reliability, test-retest reproducibility, responsiveness, and sensitivity. Some statistical issues regarding the validation of utility analysis and calibration for QOL against life events and/or disease status will also be discussed.

Full Text

Duke Authors

Cited Authors

  • Chow, SC; Ki, FY

Published Date

  • March 1996

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 37 - 48

PubMed ID

  • 8838777

Pubmed Central ID

  • 8838777

International Standard Serial Number (ISSN)

  • 1054-3406

Digital Object Identifier (DOI)

  • 10.1080/10543409608835120


  • eng

Conference Location

  • England