Statistical issues in quality-of-life assessment.

Journal Article (Journal Article)

In recent years, the assessment of drug effects on quality of life (QOL) has become very popular in clinical trials. QOL assessment quantifies the ability of a person to function normally in society. It may be used to distinguish between therapies that appear to be equally efficacious and equally safe. QOL is usually assessed by a QOL instrument, which consists of a number of questions. A QOL instrument is a very subjective tool that usually has a large variation. To ensure the accuracy and reliability of QOL assessment in clinical trials, the adopted QOL instrument should be validated. Some statistical tests are proposed for validation of a QOL instrument in terms of validity, reliability, test-retest reproducibility, responsiveness, and sensitivity. Some statistical issues regarding the validation of utility analysis and calibration for QOL against life events and/or disease status will also be discussed.

Full Text

Duke Authors

Cited Authors

  • Chow, SC; Ki, FY

Published Date

  • March 1996

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 37 - 48

PubMed ID

  • 8838777

International Standard Serial Number (ISSN)

  • 1054-3406

Digital Object Identifier (DOI)

  • 10.1080/10543409608835120


  • eng

Conference Location

  • England