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Positive and negative network correlations in temporal lobe epilepsy.

Publication ,  Journal Article
Blumenfeld, H; McNally, KA; Vanderhill, SD; Paige, AL; Chung, R; Davis, K; Norden, AD; Stokking, R; Studholme, C; Novotny, EJ; Zubal, IG; Spencer, SS
Published in: Cereb Cortex
August 2004

Temporal lobe seizures are accompanied by complex behavioral phenomena including loss of consciousness, dystonic movements and neuroendocrine changes. These phenomena may arise from extended neural networks beyond the temporal lobe. To investigate this, we imaged cerebral blood flow (CBF) changes during human temporal lobe seizures with single photon emission computed tomography (SPECT) while performing continuous video/EEG monitoring. We found that temporal lobe seizures associated with loss of consciousness produced CBF increases in the temporal lobe, followed by increases in bilateral midline subcortical structures. These changes were accompanied by marked bilateral CBF decreases in the frontal and parietal association cortex. In contrast, temporal lobe seizures in which consciousness was spared were not accompanied by these widespread CBF changes. The CBF decreases in frontal and parietal association cortex were strongly correlated with increases in midline structures such as the mediodorsal thalamus. These results suggest that impaired consciousness in temporal lobe seizures may result from focal abnormal activity in temporal and subcortical networks linked to widespread impaired function of the association cortex.

Duke Scholars

Published In

Cereb Cortex

DOI

ISSN

1047-3211

Publication Date

August 2004

Volume

14

Issue

8

Start / End Page

892 / 902

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Statistics as Topic
  • Seizures
  • Nerve Net
  • Middle Aged
  • Male
  • Image Interpretation, Computer-Assisted
  • Humans
  • Female
  • Feedback
 

Citation

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Blumenfeld, H., McNally, K. A., Vanderhill, S. D., Paige, A. L., Chung, R., Davis, K., … Spencer, S. S. (2004). Positive and negative network correlations in temporal lobe epilepsy. Cereb Cortex, 14(8), 892–902. https://doi.org/10.1093/cercor/bhh048
Blumenfeld, Hal, Kelly A. McNally, Susan D. Vanderhill, A LeBron Paige, Richard Chung, Kathryn Davis, Andrew D. Norden, et al. “Positive and negative network correlations in temporal lobe epilepsy.Cereb Cortex 14, no. 8 (August 2004): 892–902. https://doi.org/10.1093/cercor/bhh048.
Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, et al. Positive and negative network correlations in temporal lobe epilepsy. Cereb Cortex. 2004 Aug;14(8):892–902.
Blumenfeld, Hal, et al. “Positive and negative network correlations in temporal lobe epilepsy.Cereb Cortex, vol. 14, no. 8, Aug. 2004, pp. 892–902. Pubmed, doi:10.1093/cercor/bhh048.
Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, Norden AD, Stokking R, Studholme C, Novotny EJ, Zubal IG, Spencer SS. Positive and negative network correlations in temporal lobe epilepsy. Cereb Cortex. 2004 Aug;14(8):892–902.
Journal cover image

Published In

Cereb Cortex

DOI

ISSN

1047-3211

Publication Date

August 2004

Volume

14

Issue

8

Start / End Page

892 / 902

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Statistics as Topic
  • Seizures
  • Nerve Net
  • Middle Aged
  • Male
  • Image Interpretation, Computer-Assisted
  • Humans
  • Female
  • Feedback