Positive and negative network correlations in temporal lobe epilepsy.

Published

Journal Article

Temporal lobe seizures are accompanied by complex behavioral phenomena including loss of consciousness, dystonic movements and neuroendocrine changes. These phenomena may arise from extended neural networks beyond the temporal lobe. To investigate this, we imaged cerebral blood flow (CBF) changes during human temporal lobe seizures with single photon emission computed tomography (SPECT) while performing continuous video/EEG monitoring. We found that temporal lobe seizures associated with loss of consciousness produced CBF increases in the temporal lobe, followed by increases in bilateral midline subcortical structures. These changes were accompanied by marked bilateral CBF decreases in the frontal and parietal association cortex. In contrast, temporal lobe seizures in which consciousness was spared were not accompanied by these widespread CBF changes. The CBF decreases in frontal and parietal association cortex were strongly correlated with increases in midline structures such as the mediodorsal thalamus. These results suggest that impaired consciousness in temporal lobe seizures may result from focal abnormal activity in temporal and subcortical networks linked to widespread impaired function of the association cortex.

Full Text

Duke Authors

Cited Authors

  • Blumenfeld, H; McNally, KA; Vanderhill, SD; Paige, AL; Chung, R; Davis, K; Norden, AD; Stokking, R; Studholme, C; Novotny, EJ; Zubal, IG; Spencer, SS

Published Date

  • August 2004

Published In

Volume / Issue

  • 14 / 8

Start / End Page

  • 892 - 902

PubMed ID

  • 15084494

Pubmed Central ID

  • 15084494

International Standard Serial Number (ISSN)

  • 1047-3211

Digital Object Identifier (DOI)

  • 10.1093/cercor/bhh048

Language

  • eng

Conference Location

  • United States