Minireview: Nuclear receptors, hematopoiesis, and stem cells.

Journal Article (Journal Article;Review)

Nuclear receptors (NRs) regulate a panoply of biological processes, including the function and development of cells within the hematopoietic and immune system, such as erythrocytes, monocytes, and lymphocytes. Significantly less is known regarding the function of NRs in regulating the fate of hematopoietic stem cells (HSCs), the self-renewing, pluripotent cells that give rise to the entirety of the blood and immune systems throughout the lifetime of an individual. Several recent studies suggest, either directly or indirectly, a role for members of the NR family in regulating the differentiation and self-renewal of HSCs, embryonic stem cells, and induced pluripotent stem cells. Herein, we review in detail the function of specific NRs in controlling HSC and other stem cell fate and propose a framework through which these observations can be translated into therapeutic amplification of HSCs for clinical purposes.

Full Text

Duke Authors

Cited Authors

  • Chute, JP; Ross, JR; McDonnell, DP

Published Date

  • January 2010

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 1 - 10

PubMed ID

  • 19934345

Pubmed Central ID

  • PMC2802897

Electronic International Standard Serial Number (EISSN)

  • 1944-9917

Digital Object Identifier (DOI)

  • 10.1210/me.2009-0332


  • eng

Conference Location

  • United States