Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents

Journal Article

A novel series of diaminoanthraquinones was discovered initially as protein kinase C inhibitors with IC50s in the 50-100 μM range. They exhibited potent tumor cell growth inhibitory activity in vitro without cross resistance to adriamycin. Further evaluation of two of the most active compounds NSC 639365 (3) and NSC 639366 (4) in human tumor cloning assay showed potent cytocidal activity. The results suggest therapeutical potentials against human tumors. © 1992 American Chemical Society.

Duke Authors

Cited Authors

  • Jiang, JB; Johnson, MG; Defauw, JM; Beine, TM; Bellas, LM; Janzen, WP; Loomis, CR; Seldin, J; Cofield, D; Adams, L; Cianciolo, G; Degen, D; Hoff, DDV

Published Date

  • 1992

Published In

Volume / Issue

  • 35 / 23

Start / End Page

  • 4259 - 4263

International Standard Serial Number (ISSN)

  • 0022-2623