Major liver resection in elderly patients: a multi-institutional analysis.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Because of the aging United States population, increase in overall life expectancy, and rising incidence of hepatobiliary tumors, more elderly patients are considered for hepatic resection. The objective of this study was to assess the influence of age on postoperative outcomes after major hepatectomy among a contemporary cohort from 2 high volume centers. STUDY DESIGN: Demographics, diagnoses, surgical treatments, and postoperative outcomes of patients who underwent major hepatic resection were reviewed. RESULTS: There were 856 patients who underwent major hepatectomy (resection of 3 or more segments) from 2002 to 2009. Postoperative mortality and morbidity occurred in 53 (6.2%) and 403 (47.1%) patients, respectively. Increasing age was independently associated with postoperative mortality (p = 0.0345). Each 1-year and 10-year increase in age resulted in an odds ratio of mortality after major hepatic resection of 1.036 (95% CI [1.003-1.071]) and 1.426 (95% CI [1.026-1.982]), respectively. This relationship was independent of American Society of Anesthesiology (ASA) score. Increasing age was associated with postoperative sepsis (p = 0.0224, odds ratio for each year 1.025 [range 1.003 to 1.048]) after major hepatic resection, but not overall postoperative morbidity. CONCLUSIONS: In the contemporary era, increasing age is independently associated with postoperative mortality after major hepatic resection at high volume academic centers.

Full Text

Duke Authors

Cited Authors

  • Reddy, SK; Barbas, AS; Turley, RS; Gamblin, TC; Geller, DA; Marsh, JW; Tsung, A; Clary, BM; Lagoo-Deenadayalan, S

Published Date

  • May 2011

Published In

Volume / Issue

  • 212 / 5

Start / End Page

  • 787 - 795

PubMed ID

  • 21435922

Electronic International Standard Serial Number (EISSN)

  • 1879-1190

Digital Object Identifier (DOI)

  • 10.1016/j.jamcollsurg.2010.12.048


  • eng

Conference Location

  • United States