The clinical utility index as a practical multiattribute approach to drug development decisions.

Journal Article (Journal Article)

We identify some innovative approaches to predicting overall patient benefit from investigational drugs to support development decisions. We then illustrate calculation of a probabilistic clinical utility index (CUI), an implementation of multiattribute utility that focuses on clinical attributes. We recommend use of the CUI for the support of early drug development decisions because of its practicality, reasonable accuracy, and transparency to decision makers, at stages in which financial factors that may dominate later-phase decisions are less critical.

Full Text

Duke Authors

Cited Authors

  • Poland, B; Hodge, FL; Khan, A; Clemen, RT; Wagner, JA; Dykstra, K; Krishna, R

Published Date

  • July 2009

Published In

Volume / Issue

  • 86 / 1

Start / End Page

  • 105 - 108

PubMed ID

  • 19458614

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

International Standard Serial Number (ISSN)

  • 0009-9236

Digital Object Identifier (DOI)

  • 10.1038/clpt.2009.71

Language

  • eng