The clinical utility index as a practical multiattribute approach to drug development decisions.
Journal Article (Journal Article)
We identify some innovative approaches to predicting overall patient benefit from investigational drugs to support development decisions. We then illustrate calculation of a probabilistic clinical utility index (CUI), an implementation of multiattribute utility that focuses on clinical attributes. We recommend use of the CUI for the support of early drug development decisions because of its practicality, reasonable accuracy, and transparency to decision makers, at stages in which financial factors that may dominate later-phase decisions are less critical.
Full Text
Duke Authors
Cited Authors
- Poland, B; Hodge, FL; Khan, A; Clemen, RT; Wagner, JA; Dykstra, K; Krishna, R
Published Date
- July 2009
Published In
Volume / Issue
- 86 / 1
Start / End Page
- 105 - 108
PubMed ID
- 19458614
Electronic International Standard Serial Number (EISSN)
- 1532-6535
International Standard Serial Number (ISSN)
- 0009-9236
Digital Object Identifier (DOI)
- 10.1038/clpt.2009.71
Language
- eng