Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.

Journal Article (Journal Article)

Four hundred nineteen children and adolescents immunized with live varicella vaccine 4-6 years earlier were enrolled in a study to evaluate the safety and immune response to a booster dose containing approximately 3300 pfu of virus. Of the subjects, 99% (414/419) maintained antibody to varicella zoster virus (VZV) with a geometric mean titer of 25.7 and mean stimulation index (SI) for VZV-specific lymphoproliferation response of 40.3 +/- 5.3 (SE). Some 7-10 days after the booster immunization, seropositivity rates increased to 100% (302/302), and GMT was 143.6 (anamnestic response). At 6 weeks after the booster inoculation, a subset of subjects had 100% seropositivity (74/74) with a GMT of 218.8 and an SI of 58.6. After 3 months, seropositivity was 100% (358/358), GMT was 119.0, and SI was 61.4.

Full Text

Duke Authors

Cited Authors

  • Watson, B; Rothstein, E; Bernstein, H; Arbeter, A; Arvin, A; Chartrand, S; Clements, D; Kumar, ML; Reisinger, K; Blatter, M

Published Date

  • July 1995

Published In

Volume / Issue

  • 172 / 1

Start / End Page

  • 217 - 219

PubMed ID

  • 7797914

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1093/infdis/172.1.217


  • eng

Conference Location

  • United States