Scholars@Duke publication: Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.

Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.

Publication , Journal Article

Watson, B; Rothstein, E; Bernstein, H; Arbeter, A; Arvin, A; Chartrand, S; Clements, D; Kumar, ML; Reisinger, K; Blatter, M

Published in: J Infect Dis

July 1995

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Four hundred nineteen children and adolescents immunized with live varicella vaccine 4-6 years earlier were enrolled in a study to evaluate the safety and immune response to a booster dose containing approximately 3300 pfu of virus. Of the subjects, 99% (414/419) maintained antibody to varicella zoster virus (VZV) with a geometric mean titer of 25.7 and mean stimulation index (SI) for VZV-specific lymphoproliferation response of 40.3 +/- 5.3 (SE). Some 7-10 days after the booster immunization, seropositivity rates increased to 100% (302/302), and GMT was 143.6 (anamnestic response). At 6 weeks after the booster inoculation, a subset of subjects had 100% seropositivity (74/74) with a GMT of 218.8 and an SI of 58.6. After 3 months, seropositivity was 100% (358/358), GMT was 119.0, and SI was 61.4.

Duke Scholars

Author Dennis Alfred Clements III Pediatrics, General Pediatrics and Adolescent Health

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Published In

J Infect Dis

DOI

10.1093/infdis/172.1.217

ISSN

0022-1899

Publication Date

July 1995

Volume

172

Issue

Start / End Page

217 / 219

Location

United States

Related Subject Headings

Viral Vaccines
Vaccines, Attenuated
T-Lymphocytes
Safety
Microbiology
Male
Infant
Immunization, Secondary
Immunity, Cellular
Humans

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Watson, B., Rothstein, E., Bernstein, H., Arbeter, A., Arvin, A., Chartrand, S., … Blatter, M. (1995). Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization. J Infect Dis, 172(1), 217–219. https://doi.org/10.1093/infdis/172.1.217

Watson, B., E. Rothstein, H. Bernstein, A. Arbeter, A. Arvin, S. Chartrand, D. Clements, M. L. Kumar, K. Reisinger, and M. Blatter. “Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.” J Infect Dis 172, no. 1 (July 1995): 217–19. https://doi.org/10.1093/infdis/172.1.217.

Watson B, Rothstein E, Bernstein H, Arbeter A, Arvin A, Chartrand S, et al. Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization. J Infect Dis. 1995 Jul;172(1):217–9.

Watson, B., et al. “Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization.” J Infect Dis, vol. 172, no. 1, July 1995, pp. 217–19. Pubmed, doi:10.1093/infdis/172.1.217.

Watson B, Rothstein E, Bernstein H, Arbeter A, Arvin A, Chartrand S, Clements D, Kumar ML, Reisinger K, Blatter M. Safety and cellular and humoral immune responses of a booster dose of varicella vaccine 6 years after primary immunization. J Infect Dis. 1995 Jul;172(1):217–219.