Targeting genes in the renin-angiotensin system.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: The renin-angiotensin system plays a key role in the regulation of blood pressure and fluid homeostasis. Owing to its critical contribution to blood pressure control, abnormalities of any component in this system can lead to hypertension and cardiovascular diseases. In this review, we will highlight studies using this approach to uncover new perspectives on the physiology of the renin-angiotensin system. RECENT FINDINGS: Over the past decade, application of techniques for manipulating the genome of living animals, including gene targeting through homologous recombination in embryonic stem cells, has provided unique insights into the complex biology of the renin-angiotensin system. Along with advances in understanding functions of the classical components of the system, gene targeting has clarified the functions of newly discovered angiotensin-converting enzyme homologues. SUMMARY: Since pharmacological antagonists of the renin-angiotensin system are widely used in clinical medicine, advances in the gene-targeting experiments of the system have helped to clarify the mechanisms of action of these agents and may provide clues for improved approaches for the treatment of hypertension and kidney diseases.

Full Text

Duke Authors

Cited Authors

  • Le, TH; Coffman, TM

Published Date

  • January 2008

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 57 - 63

PubMed ID

  • 18090671

International Standard Serial Number (ISSN)

  • 1062-4821

Digital Object Identifier (DOI)

  • 10.1097/MNH.0b013e3282f2fd39


  • eng

Conference Location

  • England