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Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.

Publication ,  Journal Article
Bridgman, P; Aronovitz, MA; Kakkar, R; Oliverio, MI; Coffman, TM; Rand, WM; Konstam, MA; Mendelsohn, ME; Patten, RD
Published in: Am J Physiol Heart Circ Physiol
August 2005

Left ventricular (LV) remodeling after myocardial infarction (MI) results from hypertrophy of myocytes and activation of fibroblasts induced, in part, by ligand stimulation of the ANG II type 1 receptor (AT1R). The purpose of the present study was to explore the specific role for activation of the AT 1a R subtype in post-MI remodeling and whether gender differences exist in the patterns of remodeling in wild-type and AT 1a R knockout (KO) mice. AT 1a R-KO mice and wild-type littermates underwent coronary ligation to induce MI or sham procedures; echocardiography and hemodynamic evaluation were performed 6 wk later, and LV tissue was harvested for infarct size determination, morphometric measurements, and gene expression analysis. Survival and infarct size were similar among all male and female wild-type and AT 1a R-KO mice. Hemodynamic indexes were also similar except for lower systolic blood pressure in the AT 1a R-KO mice compared with wild-type mice. Male and female wild-type and male AT 1a R-KO mice developed similar increases in LV chamber size, LV mass corrected for body weight (LV/BW), and myocyte cross-sectional area (CSA). However, female AT 1a R-KO mice demonstrated no increase in LV/BW and myocyte CSA post-MI compared with shams. Both male and female wild-type mice demonstrated higher atrial natriuretic peptide (ANP) levels after MI, with female wild types being significantly greater than males. However, male and female AT 1a R-KO mice developed no increase in ANP gene expression with MI despite an increase in LV mass and myocyte size in males. These data support that gender-specific patterns of LV and myocyte hypertrophy exist after MI in mice with a disrupted AT 1a R gene, and suggest that myocyte hypertrophy post-MI in females relies, in part, on activation of the AT 1a R. Further work is necessary to explore the potential mechanisms underlying these gender-based differences.

Duke Scholars

Published In

Am J Physiol Heart Circ Physiol

DOI

ISSN

0363-6135

Publication Date

August 2005

Volume

289

Issue

2

Start / End Page

H586 / H592

Location

United States

Related Subject Headings

  • Ventricular Remodeling
  • Ventricular Function, Left
  • Survival Analysis
  • Sex Factors
  • Receptors, Angiotensin
  • Receptor, Angiotensin, Type 1
  • Myocytes, Cardiac
  • Myocardial Infarction
  • Mice, Knockout
  • Mice
 

Citation

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Bridgman, P., Aronovitz, M. A., Kakkar, R., Oliverio, M. I., Coffman, T. M., Rand, W. M., … Patten, R. D. (2005). Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. Am J Physiol Heart Circ Physiol, 289(2), H586–H592. https://doi.org/10.1152/ajpheart.00474.2004
Bridgman, Paul, Mark A. Aronovitz, Rahul Kakkar, Michael I. Oliverio, Thomas M. Coffman, William M. Rand, Marvin A. Konstam, Michael E. Mendelsohn, and Richard D. Patten. “Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.Am J Physiol Heart Circ Physiol 289, no. 2 (August 2005): H586–92. https://doi.org/10.1152/ajpheart.00474.2004.
Bridgman P, Aronovitz MA, Kakkar R, Oliverio MI, Coffman TM, Rand WM, et al. Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H586–92.
Bridgman, Paul, et al. “Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.Am J Physiol Heart Circ Physiol, vol. 289, no. 2, Aug. 2005, pp. H586–92. Pubmed, doi:10.1152/ajpheart.00474.2004.
Bridgman P, Aronovitz MA, Kakkar R, Oliverio MI, Coffman TM, Rand WM, Konstam MA, Mendelsohn ME, Patten RD. Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H586–H592.

Published In

Am J Physiol Heart Circ Physiol

DOI

ISSN

0363-6135

Publication Date

August 2005

Volume

289

Issue

2

Start / End Page

H586 / H592

Location

United States

Related Subject Headings

  • Ventricular Remodeling
  • Ventricular Function, Left
  • Survival Analysis
  • Sex Factors
  • Receptors, Angiotensin
  • Receptor, Angiotensin, Type 1
  • Myocytes, Cardiac
  • Myocardial Infarction
  • Mice, Knockout
  • Mice