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Mouse models of diabetic nephropathy.

Publication ,  Journal Article
Breyer, MD; Böttinger, E; Brosius, FC; Coffman, TM; Harris, RC; Heilig, CW; Sharma, K; AMDCC,
Published in: J Am Soc Nephrol
January 2005

Mice provide an experimental model of unparalleled flexibility for studying mammalian diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the renal complications of diabetes. Much remains to be established regarding the course of diabetic nephropathy (DN) in mice as well as defining those strains and/or mutants that are most susceptible to renal injury from diabetes. Through the use of the unique genetic reagents available in mice (including knockouts and transgenics), the validation of a mouse model reproducing human DN should significantly facilitate the understanding of the underlying genetic mechanisms that contribute to the development of DN. Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnostic and therapeutic interventions in mice before testing in humans.

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Published In

J Am Soc Nephrol

DOI

ISSN

1046-6673

Publication Date

January 2005

Volume

16

Issue

1

Start / End Page

27 / 45

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Mice
  • Disease Models, Animal
  • Diabetic Nephropathies
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 1
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
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Breyer, M. D., Böttinger, E., Brosius, F. C., Coffman, T. M., Harris, R. C., Heilig, C. W., … AMDCC, . (2005). Mouse models of diabetic nephropathy. J Am Soc Nephrol, 16(1), 27–45. https://doi.org/10.1681/ASN.2004080648
Breyer, Matthew D., Erwin Böttinger, Frank C. Brosius, Thomas M. Coffman, Raymond C. Harris, Charles W. Heilig, Kumar Sharma, and Kumar AMDCC. “Mouse models of diabetic nephropathy.J Am Soc Nephrol 16, no. 1 (January 2005): 27–45. https://doi.org/10.1681/ASN.2004080648.
Breyer MD, Böttinger E, Brosius FC, Coffman TM, Harris RC, Heilig CW, et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2005 Jan;16(1):27–45.
Breyer, Matthew D., et al. “Mouse models of diabetic nephropathy.J Am Soc Nephrol, vol. 16, no. 1, Jan. 2005, pp. 27–45. Pubmed, doi:10.1681/ASN.2004080648.
Breyer MD, Böttinger E, Brosius FC, Coffman TM, Harris RC, Heilig CW, Sharma K, AMDCC. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2005 Jan;16(1):27–45.

Published In

J Am Soc Nephrol

DOI

ISSN

1046-6673

Publication Date

January 2005

Volume

16

Issue

1

Start / End Page

27 / 45

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Mice
  • Disease Models, Animal
  • Diabetic Nephropathies
  • Diabetes Mellitus, Type 2
  • Diabetes Mellitus, Type 1
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences