Prostanoids and blood pressure: which way is up?

Journal Article (Journal Article;Review)

Members of the family of prostanoids, made up of prostaglandins and thromboxanes, are generated via COX-mediated metabolism of arachidonic acid. These lipid mediators exhibit wide-ranging biological actions that include regulating both vasomotor tone and renal sodium excretion. As COX inhibition is often associated with sodium retention leading to edema and hypertension, prostanoids appear to have a role in preventing the development of high blood pressure. On the other hand, prostaglandin E2 (PGE2) and PGI2 have also been implicated as determinants of renin secretion. A new study suggests that PGI2 plays a critical role in stimulating renin release and promoting hypertension following renal artery stenosis.

Full Text

Duke Authors

Cited Authors

  • Francois, H; Coffman, TM

Published Date

  • September 2004

Published In

Volume / Issue

  • 114 / 6

Start / End Page

  • 757 - 759

PubMed ID

  • 15372097

Pubmed Central ID

  • PMC516269

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI22929


  • eng

Conference Location

  • United States