Prostanoids and blood pressure: which way is up?
Published
Journal Article (Review)
Members of the family of prostanoids, made up of prostaglandins and thromboxanes, are generated via COX-mediated metabolism of arachidonic acid. These lipid mediators exhibit wide-ranging biological actions that include regulating both vasomotor tone and renal sodium excretion. As COX inhibition is often associated with sodium retention leading to edema and hypertension, prostanoids appear to have a role in preventing the development of high blood pressure. On the other hand, prostaglandin E2 (PGE2) and PGI2 have also been implicated as determinants of renin secretion. A new study suggests that PGI2 plays a critical role in stimulating renin release and promoting hypertension following renal artery stenosis.
Full Text
Duke Authors
Cited Authors
- Francois, H; Coffman, TM
Published Date
- September 2004
Published In
Volume / Issue
- 114 / 6
Start / End Page
- 757 - 759
PubMed ID
- 15372097
Pubmed Central ID
- 15372097
International Standard Serial Number (ISSN)
- 0021-9738
Digital Object Identifier (DOI)
- 10.1172/JCI22929
Language
- eng
Conference Location
- United States