Prostanoids and blood pressure: which way is up?
Publication
, Journal Article
Francois, H; Coffman, TM
Published in: J Clin Invest
September 2004
Members of the family of prostanoids, made up of prostaglandins and thromboxanes, are generated via COX-mediated metabolism of arachidonic acid. These lipid mediators exhibit wide-ranging biological actions that include regulating both vasomotor tone and renal sodium excretion. As COX inhibition is often associated with sodium retention leading to edema and hypertension, prostanoids appear to have a role in preventing the development of high blood pressure. On the other hand, prostaglandin E2 (PGE2) and PGI2 have also been implicated as determinants of renin secretion. A new study suggests that PGI2 plays a critical role in stimulating renin release and promoting hypertension following renal artery stenosis.
Duke Scholars
Published In
J Clin Invest
DOI
ISSN
0021-9738
Publication Date
September 2004
Volume
114
Issue
6
Start / End Page
757 / 759
Location
United States
Related Subject Headings
- Sodium
- Prostaglandins
- Prostaglandin-Endoperoxide Synthases
- Models, Biological
- Immunology
- Hypertension
- Humans
- Blood Pressure
- Animals
- 42 Health sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Francois, H., & Coffman, T. M. (2004). Prostanoids and blood pressure: which way is up? J Clin Invest, 114(6), 757–759. https://doi.org/10.1172/JCI22929
Francois, Helene, and Thomas M. Coffman. “Prostanoids and blood pressure: which way is up?” J Clin Invest 114, no. 6 (September 2004): 757–59. https://doi.org/10.1172/JCI22929.
Francois H, Coffman TM. Prostanoids and blood pressure: which way is up? J Clin Invest. 2004 Sep;114(6):757–9.
Francois, Helene, and Thomas M. Coffman. “Prostanoids and blood pressure: which way is up?” J Clin Invest, vol. 114, no. 6, Sept. 2004, pp. 757–59. Pubmed, doi:10.1172/JCI22929.
Francois H, Coffman TM. Prostanoids and blood pressure: which way is up? J Clin Invest. 2004 Sep;114(6):757–759.
Published In
J Clin Invest
DOI
ISSN
0021-9738
Publication Date
September 2004
Volume
114
Issue
6
Start / End Page
757 / 759
Location
United States
Related Subject Headings
- Sodium
- Prostaglandins
- Prostaglandin-Endoperoxide Synthases
- Models, Biological
- Immunology
- Hypertension
- Humans
- Blood Pressure
- Animals
- 42 Health sciences