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Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice.

Publication ,  Journal Article
Traynor, T; Yang, T; Huang, YG; Arend, L; Oliverio, MI; Coffman, T; Briggs, JP; Schnermann, J
Published in: Am J Physiol
December 1998

The effect of the adenosine type 1 receptor agonist N6-cyclohexyladenosine (CHA) on glomerular vascular reactivity was studied in male angiotensin II type 1A (AT1A) receptor knockout mice (9). Vascular reactivity was assessed as the response of stop-flow pressure (PSF) to infusion of CHA into loops of Henle using micropuncture techniques. In AT1A +/+ mice at ambient arterial blood pressure (96.7 +/- 2.8 mmHg), the presence of CHA (10 (-5) M) in the perfusate increased PSF responses from 6.8 +/- 0.6 to 14.3 +/- 0.9 mmHg when the loop of Henle of the index nephron was perfused and from 0.7 +/- 0.3 to 12.3 +/- 1.0 mmHg when the loop of an adjacent nephron was perfused. At reduced arterial blood pressure (82.8 +/- 1. 3 mmHg), index nephron perfusion with CHA increased PSF responses from 4.5 +/- 0.3 to 9.4 +/- 0.4 mmHg. In AT1A -/- mice with a mean arterial blood pressure of 80 +/- 1.9 mmHg, CHA increased PSF responses only from 0.1 +/- 0.3 to 3.6 +/- 0.54 mmHg during index nephron perfusion and from 0.25 +/- 0.2 to 2.7 +/- 0.55 mmHg during adjacent nephron perfusion, significantly less than in wild-type animals (P < 0.001). Responses to CHA were intermediate in AT1A +/- mice. Thus AT1A receptor knockout mice show a markedly reduced constrictor response to CHA both in the presence and absence of simultaneous activation of the tubuloglomerular feedback system. These data support the notion of a functional interaction between adenosine and angiotensin II in the regulation of afferent arteriolar tone.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

December 1998

Volume

275

Issue

6

Start / End Page

F922 / F927

Location

United States

Related Subject Headings

  • Vasomotor System
  • Vasoconstriction
  • Renal Circulation
  • Receptors, Purinergic P1
  • Receptors, Angiotensin
  • RNA, Messenger
  • Pressure
  • Perfusion
  • Mice, Knockout
  • Mice
 

Citation

APA
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MLA
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Traynor, T., Yang, T., Huang, Y. G., Arend, L., Oliverio, M. I., Coffman, T., … Schnermann, J. (1998). Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice. Am J Physiol, 275(6), F922–F927. https://doi.org/10.1152/ajprenal.1998.275.6.F922
Traynor, T., T. Yang, Y. G. Huang, L. Arend, M. I. Oliverio, T. Coffman, J. P. Briggs, and J. Schnermann. “Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice.Am J Physiol 275, no. 6 (December 1998): F922–27. https://doi.org/10.1152/ajprenal.1998.275.6.F922.
Traynor T, Yang T, Huang YG, Arend L, Oliverio MI, Coffman T, et al. Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice. Am J Physiol. 1998 Dec;275(6):F922–7.
Traynor, T., et al. “Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice.Am J Physiol, vol. 275, no. 6, Dec. 1998, pp. F922–27. Pubmed, doi:10.1152/ajprenal.1998.275.6.F922.
Traynor T, Yang T, Huang YG, Arend L, Oliverio MI, Coffman T, Briggs JP, Schnermann J. Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice. Am J Physiol. 1998 Dec;275(6):F922–F927.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

December 1998

Volume

275

Issue

6

Start / End Page

F922 / F927

Location

United States

Related Subject Headings

  • Vasomotor System
  • Vasoconstriction
  • Renal Circulation
  • Receptors, Purinergic P1
  • Receptors, Angiotensin
  • RNA, Messenger
  • Pressure
  • Perfusion
  • Mice, Knockout
  • Mice