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Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors.

Publication ,  Journal Article
Demark-Wahnefried, W; Morey, MC; Sloane, R; Snyder, DC; Miller, PE; Hartman, TJ; Cohen, HJ
Published in: J Clin Oncol
July 1, 2012

PURPOSE: Diet and exercise interventions have been tested in cancer survivors as a means to reduce late effects and comorbidity, but few have assessed adherence and health outcomes long term. METHODS: Between July 2005 and May 2007, the Reach Out to Enhance Wellness (RENEW) trial accrued 641 locoregionally staged, long-term (≥ 5 years from diagnosis) colorectal, breast, and prostate cancer survivors in the United States (21 states), Canada, and the United Kingdom. All participants were sedentary (< 150 minutes of physical activity [PA] a week), overweight or obese (body mass index, 25 to 40 kg/m(2)), and over age 65 years. The trial tested a diet-exercise intervention delivered via mailed print materials and telephone counseling. RENEW used a wait-list control, cross-over design (ie, participants received the year-long intervention immediately or after a 1-year delay), which allowed the opportunity to assess program efficacy (previously reported primary outcome), durability, and reproducibility (reported herein). Measures included diet quality (DQ), PA, BMI, and physical function (PF). RESULTS: No significant relapse was observed in the immediate-intervention arm for DQ, PA, and BMI; however, rates of functional decline increased when the intervention ceased. From year 1 to year 2, significant improvements were observed in the delayed-intervention arm; mean change scores in behaviors and BMI and PF slopes were as follows: DQ score, 5.2 (95% CI, 3.4 to 7.0); PA, 45.8 min/wk (95% CI, 26.9 to 64.6 min/wk); BMI, -0.56 (95% CI, -0.75 to -0.36); and Short Form-36 PF, -1.02 versus -5.52 (P < .001 for all measures). Overall, both arms experienced significant improvements in DQ, PA, and BMI from baseline to 2-year follow-up (P < .001). CONCLUSION: Older cancer survivors respond favorably to lifestyle interventions and make durable changes in DQ and PA that contribute to sustained weight loss. These changes positively reorient functional decline trajectories during intervention delivery.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

July 1, 2012

Volume

30

Issue

19

Start / End Page

2354 / 2361

Location

United States

Related Subject Headings

  • Survivors
  • Oncology & Carcinogenesis
  • Obesity
  • Neoplasms
  • Male
  • Humans
  • Health Behavior
  • Female
  • Exercise
  • Diet
 

Citation

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Demark-Wahnefried, W., Morey, M. C., Sloane, R., Snyder, D. C., Miller, P. E., Hartman, T. J., & Cohen, H. J. (2012). Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors. J Clin Oncol, 30(19), 2354–2361. https://doi.org/10.1200/JCO.2011.40.0895
Demark-Wahnefried, Wendy, Miriam C. Morey, Richard Sloane, Denise C. Snyder, Paige E. Miller, Terryl J. Hartman, and Harvey J. Cohen. “Reach out to enhance wellness home-based diet-exercise intervention promotes reproducible and sustainable long-term improvements in health behaviors, body weight, and physical functioning in older, overweight/obese cancer survivors.J Clin Oncol 30, no. 19 (July 1, 2012): 2354–61. https://doi.org/10.1200/JCO.2011.40.0895.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

July 1, 2012

Volume

30

Issue

19

Start / End Page

2354 / 2361

Location

United States

Related Subject Headings

  • Survivors
  • Oncology & Carcinogenesis
  • Obesity
  • Neoplasms
  • Male
  • Humans
  • Health Behavior
  • Female
  • Exercise
  • Diet