The ineffectiveness of tobramycin combination therapy in Streptococcus faecium endocarditis.


Journal Article

A patient required mitral valve replacement following ineffective antibiotic treatment of enterococcal endocarditis caused by Streptococcus faecium. Endocarditis had relapsed despite therapy with ampicillin and tobramycin for six weeks. A second relapse had occurred following treatment with penicillin and gentamicin. Initial failure of antibiotic therapy may be related to the known lack of in vitro and in vivo synergy between penicillin and tobramycin against S. faecium. Effective therapy of enterococcal endocarditis requires considerations of bacterial speciation, determination of high-level aminoglycoside resistance, and preferably adequate antibiotic synergy studies to assure effective therapy.

Full Text

Duke Authors

Cited Authors

  • Goldstein, JA; Cohen, H; Bia, FJ

Published Date

  • May 1, 1983

Published In

Volume / Issue

  • 56 / 3

Start / End Page

  • 243 - 249

PubMed ID

  • 6659563

Pubmed Central ID

  • 6659563

Electronic International Standard Serial Number (EISSN)

  • 1551-4056

International Standard Serial Number (ISSN)

  • 0044-0086


  • eng