Effectiveness of osteoporosis therapy among frail, older adults: Should we carry out more trials?
Despite the increasing number of treatment options for osteoporosis, healthcare providers continue to face clinical conundrums when deciding if and how to treat frail, older adults. The under-representation of this population in randomized controlled trials makes evidence-based decision-making difficult. Furthermore, frail, older adults have multiple medical comorbidities and other competing factors that impact fracture risk prediction. For clinicians to fully assess the potential risks and benefits of treatment, further studies that include frail, older adults are necessary. However, significant feasibility and ethical considerations may complicate trials in this population. Other complementary methodological approaches have been and will need to be utilized. With further understanding of treatment interactions with comorbidities and improvements in risk prediction models, treatment decisions may be better individualized and treatment rates improved in this population at high risk of fracture. © 2012 Future Medicine Ltd.
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