Immune heterogeneity in neuroinflammation: dendritic cells in the brain.

Published

Journal Article (Review)

Dendritic cells (DC) are critical to an integrated immune response and serve as the key link between the innate and adaptive arms of the immune system. Under steady state conditions, brain DC's act as sentinels, continually sampling their local environment. They share this function with macrophages derived from the same basic hemopoietic (bone marrow-derived) precursor and with parenchymal microglia that arise from a unique non-hemopoietic origin. While multiple cells may serve as antigen presenting cells (APCs), dendritic cells present both foreign and self-proteins to naïve T cells that, in turn, carry out effector functions that serve to protect or destroy. The resulting activation of the adaptive response is a critical step to resolution of injury or infection and is key to survival. In this review we will explore the critical roles that DCs play in the brain's response to neuroinflammatory disease with emphasis on how the brain's microenvironment impacts these actions.

Full Text

Duke Authors

Cited Authors

  • Colton, CA

Published Date

  • March 2013

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 145 - 162

PubMed ID

  • 23114889

Pubmed Central ID

  • 23114889

Electronic International Standard Serial Number (EISSN)

  • 1557-1904

Digital Object Identifier (DOI)

  • 10.1007/s11481-012-9414-8

Language

  • eng

Conference Location

  • United States