The effect of xanthine/xanthine oxidase generated reactive oxygen species on synaptic transmission.

Journal Article (Journal Article)

The effect of reactive oxygen species generated by the interaction of xanthine and xanthine oxidase on synaptic transmission was examined at the squid giant synapse and the lobster neuromuscular junction. Exposure of these synaptic regions to xanthine/xanthine oxidase produced a significant depression in evoked release, with no change in either resting membrane properties or in the action potential. Addition of catalase to the xanthine/xanthine oxidase-containing media partially blocked the synaptic depression, indicating that H2O2 contributes to the synaptic changes induced by exposure to xanthine/xanthine oxidase. H2O2 applied directly to the perfusing media also produced a decrease in synaptic efficacy. The results demonstrate that reactive oxygen species, in general, depress evoked synaptic transmission.

Full Text

Duke Authors

Cited Authors

  • Colton, C; Yao, J; Grossman, Y; Gilbert, D

Published Date

  • 1991

Published In

Volume / Issue

  • 14 / 5-6

Start / End Page

  • 385 - 393

PubMed ID

  • 1663906

International Standard Serial Number (ISSN)

  • 8755-0199

Digital Object Identifier (DOI)

  • 10.3109/10715769109093427


  • eng

Conference Location

  • Switzerland