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Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder.

Publication ,  Journal Article
Rothbaum, BO; Cahill, SP; Foa, EB; Davidson, JRT; Compton, J; Connor, KM; Astin, MC; Hahn, C-G
Published in: J Trauma Stress
October 2006

The present study was designed to determine whether augmenting sertraline with prolonged exposure (PE) would result in greater improvement than continuation with sertraline alone. Outpatient men and women with chronic PTSD completed 10 weeks of open label sertraline and then were randomly assigned to five additional weeks of sertraline alone (n = 31) or sertraline plus 10 sessions of twice-weekly PE (n = 34). Results indicated that sertraline led to a significant reduction in PTSD severity after 10 weeks but was associated with no further reductions after five more weeks. Participants who received PE showed further reduction in PTSD severity. This augmentation effect was observed only for participants who showed a partial response to medication.

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Published In

J Trauma Stress

DOI

ISSN

0894-9867

Publication Date

October 2006

Volume

19

Issue

5

Start / End Page

625 / 638

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Sertraline
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Middle Aged
  • Male
  • Long-Term Care
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

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Rothbaum, B. O., Cahill, S. P., Foa, E. B., Davidson, J. R. T., Compton, J., Connor, K. M., … Hahn, C.-G. (2006). Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder. J Trauma Stress, 19(5), 625–638. https://doi.org/10.1002/jts.20170
Rothbaum, Barbara O., Shawn P. Cahill, Edna B. Foa, Jonathan R. T. Davidson, Jill Compton, Kathryn M. Connor, Millie C. Astin, and Chang-Gyu Hahn. “Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder.J Trauma Stress 19, no. 5 (October 2006): 625–38. https://doi.org/10.1002/jts.20170.
Rothbaum BO, Cahill SP, Foa EB, Davidson JRT, Compton J, Connor KM, et al. Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder. J Trauma Stress. 2006 Oct;19(5):625–38.
Rothbaum, Barbara O., et al. “Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder.J Trauma Stress, vol. 19, no. 5, Oct. 2006, pp. 625–38. Pubmed, doi:10.1002/jts.20170.
Rothbaum BO, Cahill SP, Foa EB, Davidson JRT, Compton J, Connor KM, Astin MC, Hahn C-G. Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder. J Trauma Stress. 2006 Oct;19(5):625–638.
Journal cover image

Published In

J Trauma Stress

DOI

ISSN

0894-9867

Publication Date

October 2006

Volume

19

Issue

5

Start / End Page

625 / 638

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Sertraline
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatry
  • Middle Aged
  • Male
  • Long-Term Care
  • Humans
  • Follow-Up Studies
  • Female