Augmentation of sertraline with prolonged exposure in the treatment of posttraumatic stress disorder.

Journal Article (Journal Article;Multicenter Study)

The present study was designed to determine whether augmenting sertraline with prolonged exposure (PE) would result in greater improvement than continuation with sertraline alone. Outpatient men and women with chronic PTSD completed 10 weeks of open label sertraline and then were randomly assigned to five additional weeks of sertraline alone (n = 31) or sertraline plus 10 sessions of twice-weekly PE (n = 34). Results indicated that sertraline led to a significant reduction in PTSD severity after 10 weeks but was associated with no further reductions after five more weeks. Participants who received PE showed further reduction in PTSD severity. This augmentation effect was observed only for participants who showed a partial response to medication.

Full Text

Duke Authors

Cited Authors

  • Rothbaum, BO; Cahill, SP; Foa, EB; Davidson, JRT; Compton, J; Connor, KM; Astin, MC; Hahn, C-G

Published Date

  • October 2006

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 625 - 638

PubMed ID

  • 17075912

International Standard Serial Number (ISSN)

  • 0894-9867

Digital Object Identifier (DOI)

  • 10.1002/jts.20170


  • eng

Conference Location

  • United States