Expression of cadherin/catenin cell--cell adhesion molecules in a onychomatricoma.
Journal Article (Journal Article)
Onychomatricoma is a rare nail tumor with a distinctive architecture. Proximally, there are serum-filled invaginations of nail matrix epithelium into the stroma, and distally, dermal protrusions perforate the nail plate. Because other matrical tumors of follicular and odontogenic origin express nuclear beta-catenin, we examined the expression of cadherin/catenin proteins in this onychomatricoma case. The patient presented with a toenail yellow streak, and the biopsy revealed an onychomatricoma. E-cadherin and beta-catenin were at the cell membrane in the epithelial invaginations. P-cadherin was restricted to basal cells. In contrast to other matrical tumors, nuclear beta-catenin was not present. These results suggest that onychomatricoma may lack the transcriptional activating role of beta-catenin that characterizes follicular and odontogenic matrical tumors. This is the first report on the expression of cadherin/ catenin cell-cell adhesion proteins in this rare nail tumor.
Full Text
Duke Authors
Cited Authors
- Burchette, JL; Pham, TT; Higgins, SP; Cook, JL; Soler, AP
Published Date
- July 2008
Published In
Volume / Issue
- 16 / 3
Start / End Page
- 349 - 353
PubMed ID
- 18573792
International Standard Serial Number (ISSN)
- 1066-8969
Digital Object Identifier (DOI)
- 10.1177/1066896907310374
Language
- eng
Conference Location
- United States