Expression of cadherin/catenin cell--cell adhesion molecules in a onychomatricoma.

Journal Article

Onychomatricoma is a rare nail tumor with a distinctive architecture. Proximally, there are serum-filled invaginations of nail matrix epithelium into the stroma, and distally, dermal protrusions perforate the nail plate. Because other matrical tumors of follicular and odontogenic origin express nuclear beta-catenin, we examined the expression of cadherin/catenin proteins in this onychomatricoma case. The patient presented with a toenail yellow streak, and the biopsy revealed an onychomatricoma. E-cadherin and beta-catenin were at the cell membrane in the epithelial invaginations. P-cadherin was restricted to basal cells. In contrast to other matrical tumors, nuclear beta-catenin was not present. These results suggest that onychomatricoma may lack the transcriptional activating role of beta-catenin that characterizes follicular and odontogenic matrical tumors. This is the first report on the expression of cadherin/ catenin cell-cell adhesion proteins in this rare nail tumor.

Full Text

Duke Authors

Cited Authors

  • Burchette, JL; Pham, TT; Higgins, SP; Cook, JL; Soler, AP

Published Date

  • July 2008

Published In

Volume / Issue

  • 16 / 3

Start / End Page

  • 349 - 353

PubMed ID

  • 18573792

International Standard Serial Number (ISSN)

  • 1066-8969

Digital Object Identifier (DOI)

  • 10.1177/1066896907310374

Language

  • eng

Conference Location

  • United States