Memory impairment in elderly individuals with a mildly elevated serum TSH: The role of processing resources, depression and cerebrovascular disease

Journal Article (Journal Article)

This study examined whether a mild elevation in serum Thyroid Stimulating Hormone (TSH) in normal older individuals was associated with a cognitive impairment. Participants consisted of 15 individuals with a high-TSH level and 82 with a normal TSH. The high-TSH group performed significantly worse than the normal-TSH group of tests of immediate and delayed verbal recall and on the Mini-Mental State Exam. This decrement was not due to group differences in processing resources nor was it explained by comorbid cerebrovascular disease, depression or anticholinergic drug usage. These results suggest that undetected mild thyroid dysfunction may contribute to the cognitive decrements found in older adults.

Full Text

Duke Authors

Cited Authors

  • Cook, SE; Nebes, RD; Halligan, EM; Burmeister, LA; Saxton, JA; Ganguli, M; Fukui, MB; Meltzer, CC; Williams, RL; DeKosky, ST

Published Date

  • September 1, 2002

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • 175 - 183

International Standard Serial Number (ISSN)

  • 1382-5585

Digital Object Identifier (DOI)

  • 10.1076/anec.

Citation Source

  • Scopus