The latent class structure of ADHD is stable across informants.


Journal Article

Previous studies have looked at the structure of attention-deficit/hyperactivity disorder (ADHD) using latent class analysis (LCA) of Child Behavior Checklist (CBCL) or Diagnostic and Statistical Manual of Mental Disorders (DSM) symptom structure. These studies have identified distinct classes of children with inattentive, hyperactive, or combined subtypes and have used these classes to refine genetic analyses. The objective of the current report is to determine if the latent class structure of ADHD subtypes is consistent across informant using the Conners' Rating Scales (CRS). LCA was applied to CRS forms from mother, father, and teacher reports of 1837, 1329 and 1048 latency aged Dutch twins, respectively. The optimal solution for boys was a 5-class solution for mothers, a 3-class solution for fathers, and a 4-class solution for teachers. For girls, a 4-class solution for mothers and a 3-class for fathers and teachers was optimal. Children placed into a class by one informant had markedly increased odds ratio of being placed into the same or similar class by the other informants. Results from LCA using Dutch twins with the CRS show stability across informants suggesting that more stable phenotypes may be accessible for genotyping using a multi-informant approach.

Full Text

Duke Authors

Cited Authors

  • Althoff, RR; Copeland, WE; Stanger, C; Derks, EM; Todd, RD; Neuman, RJ; Van Beijsterveldt, TCEM; Boomsma, DI; Hudziak, JJ

Published Date

  • August 2006

Published In

Volume / Issue

  • 9 / 4

Start / End Page

  • 507 - 522

PubMed ID

  • 16899158

Pubmed Central ID

  • 16899158

International Standard Serial Number (ISSN)

  • 1832-4274

Digital Object Identifier (DOI)

  • 10.1375/183242706778025008


  • eng

Conference Location

  • England