Histoplasmosis and penicilliosis among HIV-infected Thai patients: a retrospective review.

Journal Article

Histoplasmosis and penicilliosis are fungal infections with similar clinical presentation and laboratory findings that were reported mainly in the era prior to highly active antiretroviral therapy. We conducted a retrospective review at two hospitals in Central Thailand of the medical records of HIV-positive patients with microbiologic evidence of histoplasmosis or penicilliosis between January 2003 to September 2007 when antiretrovirals became widely available in Thailand. Fifty patients met inclusion criteria; 36 had histoplasmosis, and 14 had penicilliosis. Symptoms and laboratory findings on presentation were similar between the two infections except for a greater incidence of tachypnea and neutropenia among patients with histoplasmosis (both p < 0.05). For histoplasmosis, blood culture had a significantly lower yield for detecting infection compared to tissue microscopic examination highlighting the importance of obtaining tissue for diagnosis (p < 0.05).

Full Text

Duke Authors

Cited Authors

  • Rangwala, F; Putcharoen, O; Bowonwatanuwong, C; Edwards-Jackson, N; Kramomthong, S; Kim, JH; Corey, GR; Ananworanich, J

Published Date

  • March 2012

Published In

Volume / Issue

  • 43 / 2

Start / End Page

  • 436 - 441

PubMed ID

  • 23082594

International Standard Serial Number (ISSN)

  • 0125-1562

Language

  • eng

Conference Location

  • Thailand