Telavancin for the treatment of serious gram-positive infections, including hospital acquired pneumonia.
Journal Article (Journal Article;Review)
INTRODUCTION: Hospital-acquired pneumonia is a common infection, associated with substantial mortality. Despite the increasing prevalence of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA), approved treatment options for this pathogen are limited. AREAS COVERED: This article reviews the pharmacokinetics, dosing, preclinical studies and clinical efficacy, and safety of telavancin, with a particular focus on results from trials in nosocomial pneumonia. PubMed and Congress websites were searched for relevant articles published between 2003 and 2010. EXPERT OPINION: Telavancin is a lipoglycopeptide antibiotic with rapid, bactericidal activity against MRSA, and may provide another option for the treatment of nosocomial pneumonia, owing to Gram-positive pathogens.
Full Text
Duke Authors
Cited Authors
- Rubinstein, E; Corey, GR; Stryjewski, ME; Kanafani, ZA
Published Date
- December 2011
Published In
Volume / Issue
- 12 / 17
Start / End Page
- 2737 - 2750
PubMed ID
- 22077833
Electronic International Standard Serial Number (EISSN)
- 1744-7666
Digital Object Identifier (DOI)
- 10.1517/14656566.2011.633511
Language
- eng
Conference Location
- England