Performance of recombinant K39 antigen in the diagnosis of Brazilian visceral leishmaniasis

Journal Article

This study evaluated the performance of recombinant K39 (rK39) antigen in a immunochromatographic format (strip test) and a crude antigen enzyme-linked immunosorbent assay in the diagnosis of Brazilian visceral leishmaniasis (VL) in 128 consecutive patients with parasitologically proven infections (by microscopy and/or culture). For each patient, a medical history was obtained and a complete physical examination was performed. Controls included 10 healthy volunteers and 50 patients with other diseases: malaria (10), leprosy (9), Chagas' disease (10), tuberculosis (10), and cutaneous leishmaniasis (11). The sensitivities of the rK39 antigen strip test and the ELISA were 90% and 89%, respectively, while the specificities were 100% and 98%, respectively. Our study confirms the accuracy of the rK39 antigen strip test in the diagnosis of VL in a high prevalence population.

Duke Authors

Cited Authors

  • Carvalho, SFG; Lemos, EM; Corey, R; Dietze, R

Published Date

  • 2003

Published In

  • American Journal of Tropical Medicine and Hygiene

Volume / Issue

  • 68 / 3

Start / End Page

  • 321 - 324

PubMed ID

  • 12685638