Role of vasoactive mediators in the pathogenesis of Chagas' disease.

Journal Article (Journal Article;Review)

This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoactive peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

Full Text

Duke Authors

Cited Authors

  • Mukherjee, S; Huang, H; Weiss, LM; Costa, S; Scharfstein, J; Tanowitz, HB

Published Date

  • May 1, 2003

Published In

Volume / Issue

  • 8 /

Start / End Page

  • e410 - e419

PubMed ID

  • 12700081

International Standard Serial Number (ISSN)

  • 1093-9946

Digital Object Identifier (DOI)

  • 10.2741/1103


  • eng

Conference Location

  • United States