Role of vasoactive mediators in the pathogenesis of Chagas' disease
Publication
, Journal Article
Mukherjee, S; Huang, H; Weiss, LM; Costa, S; Scharfstein, J; Tanowitz, HB
Published in: Frontiers in Bioscience
January 1, 2003
This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoative peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.
Duke Scholars
Published In
Frontiers in Bioscience
EISSN
2768-6698
ISSN
2768-6701
Publication Date
January 1, 2003
Volume
8
Related Subject Headings
- 3207 Medical microbiology
- 3205 Medical biochemistry and metabolomics
- 3102 Bioinformatics and computational biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Mukherjee, S., Huang, H., Weiss, L. M., Costa, S., Scharfstein, J., & Tanowitz, H. B. (2003). Role of vasoactive mediators in the pathogenesis of Chagas' disease. Frontiers in Bioscience, 8.
Mukherjee, S., H. Huang, L. M. Weiss, S. Costa, J. Scharfstein, and H. B. Tanowitz. “Role of vasoactive mediators in the pathogenesis of Chagas' disease.” Frontiers in Bioscience 8 (January 1, 2003).
Mukherjee S, Huang H, Weiss LM, Costa S, Scharfstein J, Tanowitz HB. Role of vasoactive mediators in the pathogenesis of Chagas' disease. Frontiers in Bioscience. 2003 Jan 1;8.
Mukherjee, S., et al. “Role of vasoactive mediators in the pathogenesis of Chagas' disease.” Frontiers in Bioscience, vol. 8, Jan. 2003.
Mukherjee S, Huang H, Weiss LM, Costa S, Scharfstein J, Tanowitz HB. Role of vasoactive mediators in the pathogenesis of Chagas' disease. Frontiers in Bioscience. 2003 Jan 1;8.
Published In
Frontiers in Bioscience
EISSN
2768-6698
ISSN
2768-6701
Publication Date
January 1, 2003
Volume
8
Related Subject Headings
- 3207 Medical microbiology
- 3205 Medical biochemistry and metabolomics
- 3102 Bioinformatics and computational biology