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Role of vasoactive mediators in the pathogenesis of Chagas' disease

Publication ,  Journal Article
Mukherjee, S; Huang, H; Weiss, LM; Costa, S; Scharfstein, J; Tanowitz, HB
Published in: Frontiers in Bioscience
January 1, 2003

This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoative peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

Duke Scholars

Published In

Frontiers in Bioscience

EISSN

2768-6698

ISSN

2768-6701

Publication Date

January 1, 2003

Volume

8

Related Subject Headings

  • 3207 Medical microbiology
  • 3205 Medical biochemistry and metabolomics
  • 3102 Bioinformatics and computational biology
 

Citation

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Mukherjee, S., Huang, H., Weiss, L. M., Costa, S., Scharfstein, J., & Tanowitz, H. B. (2003). Role of vasoactive mediators in the pathogenesis of Chagas' disease. Frontiers in Bioscience, 8.
Mukherjee, S., H. Huang, L. M. Weiss, S. Costa, J. Scharfstein, and H. B. Tanowitz. “Role of vasoactive mediators in the pathogenesis of Chagas' disease.” Frontiers in Bioscience 8 (January 1, 2003).
Mukherjee S, Huang H, Weiss LM, Costa S, Scharfstein J, Tanowitz HB. Role of vasoactive mediators in the pathogenesis of Chagas' disease. Frontiers in Bioscience. 2003 Jan 1;8.
Mukherjee, S., et al. “Role of vasoactive mediators in the pathogenesis of Chagas' disease.” Frontiers in Bioscience, vol. 8, Jan. 2003.
Mukherjee S, Huang H, Weiss LM, Costa S, Scharfstein J, Tanowitz HB. Role of vasoactive mediators in the pathogenesis of Chagas' disease. Frontiers in Bioscience. 2003 Jan 1;8.

Published In

Frontiers in Bioscience

EISSN

2768-6698

ISSN

2768-6701

Publication Date

January 1, 2003

Volume

8

Related Subject Headings

  • 3207 Medical microbiology
  • 3205 Medical biochemistry and metabolomics
  • 3102 Bioinformatics and computational biology