NMR spin-lattice relaxation in tissues with high concentration of paramagnetic contrast media: evaluation of water exchange rates in intact rat muscle.


Journal Article

High concentrations of GdDTPA in extracellular water of tissue cause the intrinsic relaxation rate of water to become greater than the coupling rate between intracellular and extracellular water compartments. The fast exchange limit is no longer valid and distinctly nonexponential spin-lattice recovery is observed. T1 relaxation recovery was characterized by a double exponential curve when striated rat muscle was immersed in a highly concentrated (110 Mm) isotonic solution of GdDTPA. When the water exchange rate through cell membranes in intact muscle tissue was calculated (using a two-compartment exchange model) and compared to similar data determined from T2 Carr-Purcell-Meiboom-Gill experiments, a significant discrepancy was found.

Full Text

Duke Authors

Cited Authors

  • Sobol, WT; Jackels, SC; Cothran, RL; Hinson, WH

Published Date

  • March 1, 1991

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 243 - 250

PubMed ID

  • 2046611

Pubmed Central ID

  • 2046611

International Standard Serial Number (ISSN)

  • 0094-2405

Digital Object Identifier (DOI)

  • 10.1118/1.596722


  • eng

Conference Location

  • United States