Skip to main content
Journal cover image

Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis.

Publication ,  Journal Article
Lin, CB; Hornik, CP; Clark, R; Cotten, CM; Benjamin, DK; Cohen-Wolkoweiz, M; Smith, PB; Wynn, JL
Published in: Early Hum Dev
November 2012

BACKGROUND: Very low birth weight neonates (≤ 1500 g, VLBWs) have a high rate of infection and distinct baseline immune function compared with more mature populations. In critically ill children and adults, sepsis increases subsequent infection risk. It is unknown whether sepsis modifies the risk of subsequent infection in VLBWs. METHODS: We conducted a retrospective cohort study of VLBWs≤32weeks of gestation at birth cared for in 312 neonatal intensive care units in the United States from 1997 to 2011 (n=103,376). Early-onset sepsis (EOS, culture-positive only) and late-onset sepsis (LOS, culture-positive or clinical) cases were identified. Cox proportional hazard models were used to control for clinical variables between neonates with and without EOS to determine if EOS modified risk of LOS, necrotizing enterocolitis (NEC), or death. RESULTS: LOS occurred in 12,112/102,317 (11.8%) neonates without EOS and in 133/1059 (12.6%) of those with EOS. After adjustment for clinical variables, the risk of LOS was not different between neonates with or without a history of EOS (hazard ratio [HR]=0.92; 95% confidence interval [CI] 0.74, 1.16). EOS increased the risk of 120-day mortality (HR=1.78; 95% CI 1.49, 2.13). CONCLUSIONS: In contrast to findings in children and adults, EOS was not associated with an increased risk of LOS in this cohort. Age-specific investigations are needed to determine if post-sepsis immunologic alterations are present.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

November 2012

Volume

88

Issue

11

Start / End Page

905 / 909

Location

Ireland

Related Subject Headings

  • Sepsis
  • Risk Factors
  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Infant, Extremely Premature
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lin, C. B., Hornik, C. P., Clark, R., Cotten, C. M., Benjamin, D. K., Cohen-Wolkoweiz, M., … Wynn, J. L. (2012). Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis. Early Hum Dev, 88(11), 905–909. https://doi.org/10.1016/j.earlhumdev.2012.07.009
Lin, Cheryl B., Christoph P. Hornik, Reese Clark, C Michael Cotten, Daniel K. Benjamin, Michael Cohen-Wolkoweiz, P Brian Smith, and James L. Wynn. “Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis.Early Hum Dev 88, no. 11 (November 2012): 905–9. https://doi.org/10.1016/j.earlhumdev.2012.07.009.
Lin CB, Hornik CP, Clark R, Cotten CM, Benjamin DK, Cohen-Wolkoweiz M, et al. Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis. Early Hum Dev. 2012 Nov;88(11):905–9.
Lin, Cheryl B., et al. “Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis.Early Hum Dev, vol. 88, no. 11, Nov. 2012, pp. 905–09. Pubmed, doi:10.1016/j.earlhumdev.2012.07.009.
Lin CB, Hornik CP, Clark R, Cotten CM, Benjamin DK, Cohen-Wolkoweiz M, Smith PB, Wynn JL. Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis. Early Hum Dev. 2012 Nov;88(11):905–909.
Journal cover image

Published In

Early Hum Dev

DOI

EISSN

1872-6232

Publication Date

November 2012

Volume

88

Issue

11

Start / End Page

905 / 909

Location

Ireland

Related Subject Headings

  • Sepsis
  • Risk Factors
  • Pediatrics
  • Male
  • Infant, Very Low Birth Weight
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
  • Infant, Extremely Premature
  • Humans