Metoclopramide, H2 blockers, and proton pump inhibitors: pharmacotherapy for gastroesophageal reflux in neonates.

Journal Article (Journal Article;Review)

Pharmacotherapy for gastroesophageal reflux (GER) in neonates, aimed at interfering with this physiologic process and potentially reducing the negative sequelae that providers often attribute to GER, consists primarily of drugs that increase the viscosity of feeds, reduce stomach acidity, or improve gut motility. Medications used to treat clinical signs thought to be from GER, such as apnea, bradycardia, or feeding intolerance, are among the most commonly prescribed medications in neonatal intensive care units in the United States, despite the lack of evidence of safety and efficacy in this population.

Full Text

Duke Authors

Cited Authors

  • Malcolm, WF; Cotten, CM

Published Date

  • March 2012

Published In

Volume / Issue

  • 39 / 1

Start / End Page

  • 99 - 109

PubMed ID

  • 22341540

Electronic International Standard Serial Number (EISSN)

  • 1557-9840

Digital Object Identifier (DOI)

  • 10.1016/j.clp.2011.12.015


  • eng

Conference Location

  • United States