Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.

Journal Article (Journal Article)

The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such transformation and in some cases also tumorigenesis depend upon S194 of RalA, a known Aurora-A phosphorylation site. Aurora-A promotes not only RalA activation but also translocation from the plasma membrane and activation of the effector protein RalBP1. Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA.

Full Text

Duke Authors

Cited Authors

  • Lim, K-H; Brady, DC; Kashatus, DF; Ancrile, BB; Der, CJ; Cox, AD; Counter, CM

Published Date

  • January 2010

Published In

Volume / Issue

  • 30 / 2

Start / End Page

  • 508 - 523

PubMed ID

  • 19901077

Pubmed Central ID

  • PMC2798468

Electronic International Standard Serial Number (EISSN)

  • 1098-5549

Digital Object Identifier (DOI)

  • 10.1128/MCB.00916-08

Language

  • eng

Conference Location

  • United States