Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.
Journal Article (Journal Article)
The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such transformation and in some cases also tumorigenesis depend upon S194 of RalA, a known Aurora-A phosphorylation site. Aurora-A promotes not only RalA activation but also translocation from the plasma membrane and activation of the effector protein RalBP1. Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA.
Full Text
Duke Authors
Cited Authors
- Lim, K-H; Brady, DC; Kashatus, DF; Ancrile, BB; Der, CJ; Cox, AD; Counter, CM
Published Date
- January 2010
Published In
Volume / Issue
- 30 / 2
Start / End Page
- 508 - 523
PubMed ID
- 19901077
Pubmed Central ID
- PMC2798468
Electronic International Standard Serial Number (EISSN)
- 1098-5549
Digital Object Identifier (DOI)
- 10.1128/MCB.00916-08
Language
- eng
Conference Location
- United States