A method to generate genetically defined tumors in pigs.

Journal Article (Journal Article)

As a biomedical model, pigs offer many advantages and hence have been utilized extensively for toxicology, Crohn's disease, diabetes, and organ transplantation, as well as many other research areas. However, the advantages of porcine models, particularly its large size and similarity to humans, were not exploited previously to any large degree for cancer research. One reason for this lack of porcine cancer models was the inability to induce cancer in pigs genetically. This chapter describes a rapid, reproducible, and genetically malleable method to induce large tumors in pigs.

Full Text

Duke Authors

Cited Authors

  • Adam, SJ; Counter, CM

Published Date

  • 2008

Published In

Volume / Issue

  • 439 /

Start / End Page

  • 39 - 51

PubMed ID

  • 18374155

Pubmed Central ID

  • PMC2688827

International Standard Serial Number (ISSN)

  • 0076-6879

Digital Object Identifier (DOI)

  • 10.1016/S0076-6879(07)00404-1


  • eng

Conference Location

  • United States