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A method to generate genetically defined tumors in pigs.

Publication ,  Journal Article
Adam, SJ; Counter, CM
Published in: Methods Enzymol
2008

As a biomedical model, pigs offer many advantages and hence have been utilized extensively for toxicology, Crohn's disease, diabetes, and organ transplantation, as well as many other research areas. However, the advantages of porcine models, particularly its large size and similarity to humans, were not exploited previously to any large degree for cancer research. One reason for this lack of porcine cancer models was the inability to induce cancer in pigs genetically. This chapter describes a rapid, reproducible, and genetically malleable method to induce large tumors in pigs.

Duke Scholars

Published In

Methods Enzymol

DOI

ISSN

0076-6879

Publication Date

2008

Volume

439

Start / End Page

39 / 51

Location

United States

Related Subject Headings

  • Transgenes
  • Swine
  • Reverse Transcriptase Polymerase Chain Reaction
  • Neoplasms
  • Humans
  • Ear, External
  • Disease Models, Animal
  • Cell Transformation, Neoplastic
  • Biochemistry & Molecular Biology
  • Animals
 

Citation

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Adam, S. J., & Counter, C. M. (2008). A method to generate genetically defined tumors in pigs. Methods Enzymol, 439, 39–51. https://doi.org/10.1016/S0076-6879(07)00404-1
Adam, Stacey J., and Christopher M. Counter. “A method to generate genetically defined tumors in pigs.Methods Enzymol 439 (2008): 39–51. https://doi.org/10.1016/S0076-6879(07)00404-1.
Adam SJ, Counter CM. A method to generate genetically defined tumors in pigs. Methods Enzymol. 2008;439:39–51.
Adam, Stacey J., and Christopher M. Counter. “A method to generate genetically defined tumors in pigs.Methods Enzymol, vol. 439, 2008, pp. 39–51. Pubmed, doi:10.1016/S0076-6879(07)00404-1.
Adam SJ, Counter CM. A method to generate genetically defined tumors in pigs. Methods Enzymol. 2008;439:39–51.
Journal cover image

Published In

Methods Enzymol

DOI

ISSN

0076-6879

Publication Date

2008

Volume

439

Start / End Page

39 / 51

Location

United States

Related Subject Headings

  • Transgenes
  • Swine
  • Reverse Transcriptase Polymerase Chain Reaction
  • Neoplasms
  • Humans
  • Ear, External
  • Disease Models, Animal
  • Cell Transformation, Neoplastic
  • Biochemistry & Molecular Biology
  • Animals