A method to generate genetically defined tumors in pigs.
Publication
, Journal Article
Adam, SJ; Counter, CM
Published in: Methods Enzymol
2008
As a biomedical model, pigs offer many advantages and hence have been utilized extensively for toxicology, Crohn's disease, diabetes, and organ transplantation, as well as many other research areas. However, the advantages of porcine models, particularly its large size and similarity to humans, were not exploited previously to any large degree for cancer research. One reason for this lack of porcine cancer models was the inability to induce cancer in pigs genetically. This chapter describes a rapid, reproducible, and genetically malleable method to induce large tumors in pigs.
Duke Scholars
Published In
Methods Enzymol
DOI
ISSN
0076-6879
Publication Date
2008
Volume
439
Start / End Page
39 / 51
Location
United States
Related Subject Headings
- Transgenes
- Swine
- Reverse Transcriptase Polymerase Chain Reaction
- Neoplasms
- Humans
- Ear, External
- Disease Models, Animal
- Cell Transformation, Neoplastic
- Biochemistry & Molecular Biology
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Adam, S. J., & Counter, C. M. (2008). A method to generate genetically defined tumors in pigs. Methods Enzymol, 439, 39–51. https://doi.org/10.1016/S0076-6879(07)00404-1
Adam, Stacey J., and Christopher M. Counter. “A method to generate genetically defined tumors in pigs.” Methods Enzymol 439 (2008): 39–51. https://doi.org/10.1016/S0076-6879(07)00404-1.
Adam SJ, Counter CM. A method to generate genetically defined tumors in pigs. Methods Enzymol. 2008;439:39–51.
Adam, Stacey J., and Christopher M. Counter. “A method to generate genetically defined tumors in pigs.” Methods Enzymol, vol. 439, 2008, pp. 39–51. Pubmed, doi:10.1016/S0076-6879(07)00404-1.
Adam SJ, Counter CM. A method to generate genetically defined tumors in pigs. Methods Enzymol. 2008;439:39–51.
Published In
Methods Enzymol
DOI
ISSN
0076-6879
Publication Date
2008
Volume
439
Start / End Page
39 / 51
Location
United States
Related Subject Headings
- Transgenes
- Swine
- Reverse Transcriptase Polymerase Chain Reaction
- Neoplasms
- Humans
- Ear, External
- Disease Models, Animal
- Cell Transformation, Neoplastic
- Biochemistry & Molecular Biology
- Animals