A method to generate genetically defined tumors in pigs.
Journal Article (Journal Article)
As a biomedical model, pigs offer many advantages and hence have been utilized extensively for toxicology, Crohn's disease, diabetes, and organ transplantation, as well as many other research areas. However, the advantages of porcine models, particularly its large size and similarity to humans, were not exploited previously to any large degree for cancer research. One reason for this lack of porcine cancer models was the inability to induce cancer in pigs genetically. This chapter describes a rapid, reproducible, and genetically malleable method to induce large tumors in pigs.
Full Text
Duke Authors
Cited Authors
- Adam, SJ; Counter, CM
Published Date
- 2008
Published In
Volume / Issue
- 439 /
Start / End Page
- 39 - 51
PubMed ID
- 18374155
Pubmed Central ID
- PMC2688827
International Standard Serial Number (ISSN)
- 0076-6879
Digital Object Identifier (DOI)
- 10.1016/S0076-6879(07)00404-1
Language
- eng
Conference Location
- United States