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Fundus autofluorescence imaging in age-related macular degeneration and geographic atrophy.

Publication ,  Journal Article
Bearelly, S; Cousins, SW
Published in: Adv Exp Med Biol
2010

The traditional method for documenting and quantifying geographic atrophy (GA) is color photography. This method has been shown to be reproducible in several clinical trials, including the Age-related Eye Disease Study (AREDS) and the natural progression of GA studies by Sunness et al. (AREDS No. 6, Am J Ophthalmol 132(5):668-681, 2001; Sunness et al., Invest Ophthalmol Vis Sci 40(8):1761-1769, 1999). Nevertheless, it can be difficult to distinguish between dead/nonfunctioning retinal pigment epithelium (RPE), living but depigmented RPE (RPE often release melanin granules upon injury), and yellowish coloration caused by large drusen or calcified regressed drusen. Two imaging technologies that seem promising are fundus autofluorescence (FAF) and spectral domain (high resolution) optical coherence tomography (SDOCT). Here we provide an overview of FAF imaging in the setting of age-related macular degeneration (AMD) and GA.

Duke Scholars

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2010

Volume

664

Start / End Page

395 / 402

Location

United States

Related Subject Headings

  • Retinal Drusen
  • Humans
  • Geographic Atrophy
  • General & Internal Medicine
  • Fundus Oculi
  • Fluorescence
  • Disease Progression
  • Diagnostic Imaging
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bearelly, S., & Cousins, S. W. (2010). Fundus autofluorescence imaging in age-related macular degeneration and geographic atrophy. Adv Exp Med Biol, 664, 395–402. https://doi.org/10.1007/978-1-4419-1399-9_45
Bearelly, Srilaxmi, and Scott W. Cousins. “Fundus autofluorescence imaging in age-related macular degeneration and geographic atrophy.Adv Exp Med Biol 664 (2010): 395–402. https://doi.org/10.1007/978-1-4419-1399-9_45.
Bearelly S, Cousins SW. Fundus autofluorescence imaging in age-related macular degeneration and geographic atrophy. Adv Exp Med Biol. 2010;664:395–402.
Bearelly, Srilaxmi, and Scott W. Cousins. “Fundus autofluorescence imaging in age-related macular degeneration and geographic atrophy.Adv Exp Med Biol, vol. 664, 2010, pp. 395–402. Pubmed, doi:10.1007/978-1-4419-1399-9_45.
Bearelly S, Cousins SW. Fundus autofluorescence imaging in age-related macular degeneration and geographic atrophy. Adv Exp Med Biol. 2010;664:395–402.

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2010

Volume

664

Start / End Page

395 / 402

Location

United States

Related Subject Headings

  • Retinal Drusen
  • Humans
  • Geographic Atrophy
  • General & Internal Medicine
  • Fundus Oculi
  • Fluorescence
  • Disease Progression
  • Diagnostic Imaging
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences