Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility.

Published

Journal Article

The purpose of this study was ultrastructural characterization of liposomes-entrapped chondroitin sulphate and to prove their in vitro biocompatibility in a human dermal fibroblast culture system, in order to use liposome-entrapped chondroitin sulphate in the treatment of inflammatory disorders. Chondroitin sulphate entrapped in liposomes appears as electron-dense particles in ultra-thin section. Comparative studies using chondroitin sulphate, empty liposomes and liposome-chondroitin sulphate systems were performed in order to evaluate their effect on growth and morphology of fibroblasts after 48 h of culture. Light microscopy indicated that chondroitin sulphate, empty liposomes and liposome-chondroitin sulphate systems do not induce appreciable cytotoxic effects, and cells maintain normal morphology when compared to control fibroblasts.

Full Text

Duke Authors

Cited Authors

  • Trif, M; Moldovan, L; Moisei, M; Craciunescu, O; Zarnescu, O

Published Date

  • October 2008

Published In

Volume / Issue

  • 39 / 7

Start / End Page

  • 1042 - 1045

PubMed ID

  • 18296058

Pubmed Central ID

  • 18296058

International Standard Serial Number (ISSN)

  • 0968-4328

Digital Object Identifier (DOI)

  • 10.1016/j.micron.2008.01.008

Language

  • eng

Conference Location

  • England