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Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility.

Publication ,  Journal Article
Trif, M; Moldovan, L; Moisei, M; Craciunescu, O; Zarnescu, O
Published in: Micron
October 2008

The purpose of this study was ultrastructural characterization of liposomes-entrapped chondroitin sulphate and to prove their in vitro biocompatibility in a human dermal fibroblast culture system, in order to use liposome-entrapped chondroitin sulphate in the treatment of inflammatory disorders. Chondroitin sulphate entrapped in liposomes appears as electron-dense particles in ultra-thin section. Comparative studies using chondroitin sulphate, empty liposomes and liposome-chondroitin sulphate systems were performed in order to evaluate their effect on growth and morphology of fibroblasts after 48 h of culture. Light microscopy indicated that chondroitin sulphate, empty liposomes and liposome-chondroitin sulphate systems do not induce appreciable cytotoxic effects, and cells maintain normal morphology when compared to control fibroblasts.

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Published In

Micron

DOI

ISSN

0968-4328

Publication Date

October 2008

Volume

39

Issue

7

Start / End Page

1042 / 1045

Location

England

Related Subject Headings

  • Microscopy, Polarization
  • Microscopy, Electron, Transmission
  • Microscopy
  • Liposomes
  • Humans
  • Fibroblasts
  • Drug Delivery Systems
  • Chondroitin Sulfates
  • Cells, Cultured
  • 5104 Condensed matter physics
 

Citation

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Trif, M., Moldovan, L., Moisei, M., Craciunescu, O., & Zarnescu, O. (2008). Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility. Micron, 39(7), 1042–1045. https://doi.org/10.1016/j.micron.2008.01.008
Trif, Mihaela, Lucia Moldovan, Magdalena Moisei, Oana Craciunescu, and Otilia Zarnescu. “Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility.Micron 39, no. 7 (October 2008): 1042–45. https://doi.org/10.1016/j.micron.2008.01.008.
Trif M, Moldovan L, Moisei M, Craciunescu O, Zarnescu O. Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility. Micron. 2008 Oct;39(7):1042–5.
Trif, Mihaela, et al. “Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility.Micron, vol. 39, no. 7, Oct. 2008, pp. 1042–45. Pubmed, doi:10.1016/j.micron.2008.01.008.
Trif M, Moldovan L, Moisei M, Craciunescu O, Zarnescu O. Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility. Micron. 2008 Oct;39(7):1042–1045.
Journal cover image

Published In

Micron

DOI

ISSN

0968-4328

Publication Date

October 2008

Volume

39

Issue

7

Start / End Page

1042 / 1045

Location

England

Related Subject Headings

  • Microscopy, Polarization
  • Microscopy, Electron, Transmission
  • Microscopy
  • Liposomes
  • Humans
  • Fibroblasts
  • Drug Delivery Systems
  • Chondroitin Sulfates
  • Cells, Cultured
  • 5104 Condensed matter physics