Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility.
The purpose of this study was ultrastructural characterization of liposomes-entrapped chondroitin sulphate and to prove their in vitro biocompatibility in a human dermal fibroblast culture system, in order to use liposome-entrapped chondroitin sulphate in the treatment of inflammatory disorders. Chondroitin sulphate entrapped in liposomes appears as electron-dense particles in ultra-thin section. Comparative studies using chondroitin sulphate, empty liposomes and liposome-chondroitin sulphate systems were performed in order to evaluate their effect on growth and morphology of fibroblasts after 48 h of culture. Light microscopy indicated that chondroitin sulphate, empty liposomes and liposome-chondroitin sulphate systems do not induce appreciable cytotoxic effects, and cells maintain normal morphology when compared to control fibroblasts.
Duke Scholars
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Related Subject Headings
- Microscopy, Polarization
- Microscopy, Electron, Transmission
- Microscopy
- Liposomes
- Humans
- Fibroblasts
- Drug Delivery Systems
- Chondroitin Sulfates
- Cells, Cultured
- 5104 Condensed matter physics
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Microscopy, Polarization
- Microscopy, Electron, Transmission
- Microscopy
- Liposomes
- Humans
- Fibroblasts
- Drug Delivery Systems
- Chondroitin Sulfates
- Cells, Cultured
- 5104 Condensed matter physics