Stem cell factor is a potent synergistic factor in hematopoiesis.
Publication
, Journal Article
Morstyn, G; Brown, S; Gordon, M; Crawford, J; Demetri, G; Rich, W; McGuire, B; Foote, M; McNiece, I
Published in: Oncology
1994
Stem cell factor (SCF), a ligand for c-kit, has a broad range of activities including effects on cells at or near the level of the multipotential stem cell as well as on committed cells. Preclinical studies show that SCF can protect against lethal irradiation, elicit multilineage responses in peripheral blood and bone marrow cellularity, and increase circulating peripheral blood progenitor cells (PBPC) in a dose-dependent manner. Recombinant human SCF has major clinical potential through its synergy with other factors, especially recombinant human granulocyte colony-stimulating factor, to enhance mobilization of PBPC.
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Published In
Oncology
DOI
ISSN
0030-2414
Publication Date
1994
Volume
51
Issue
2
Start / End Page
205 / 214
Location
Switzerland
Related Subject Headings
- Stem Cell Factor
- Oncology & Carcinogenesis
- Neoplasms
- In Vitro Techniques
- Humans
- Hematopoietic Stem Cells
- Hematopoietic Cell Growth Factors
- Hematopoiesis
- Cell Division
- Cell Differentiation
Citation
APA
Chicago
ICMJE
MLA
NLM
Morstyn, G., Brown, S., Gordon, M., Crawford, J., Demetri, G., Rich, W., … McNiece, I. (1994). Stem cell factor is a potent synergistic factor in hematopoiesis. Oncology, 51(2), 205–214. https://doi.org/10.1159/000227335
Morstyn, G., S. Brown, M. Gordon, J. Crawford, G. Demetri, W. Rich, B. McGuire, M. Foote, and I. McNiece. “Stem cell factor is a potent synergistic factor in hematopoiesis.” Oncology 51, no. 2 (1994): 205–14. https://doi.org/10.1159/000227335.
Morstyn G, Brown S, Gordon M, Crawford J, Demetri G, Rich W, et al. Stem cell factor is a potent synergistic factor in hematopoiesis. Oncology. 1994;51(2):205–14.
Morstyn, G., et al. “Stem cell factor is a potent synergistic factor in hematopoiesis.” Oncology, vol. 51, no. 2, 1994, pp. 205–14. Pubmed, doi:10.1159/000227335.
Morstyn G, Brown S, Gordon M, Crawford J, Demetri G, Rich W, McGuire B, Foote M, McNiece I. Stem cell factor is a potent synergistic factor in hematopoiesis. Oncology. 1994;51(2):205–214.
Published In
Oncology
DOI
ISSN
0030-2414
Publication Date
1994
Volume
51
Issue
2
Start / End Page
205 / 214
Location
Switzerland
Related Subject Headings
- Stem Cell Factor
- Oncology & Carcinogenesis
- Neoplasms
- In Vitro Techniques
- Humans
- Hematopoietic Stem Cells
- Hematopoietic Cell Growth Factors
- Hematopoiesis
- Cell Division
- Cell Differentiation