Stem cell factor is a potent synergistic factor in hematopoiesis.

Published

Journal Article (Review)

Stem cell factor (SCF), a ligand for c-kit, has a broad range of activities including effects on cells at or near the level of the multipotential stem cell as well as on committed cells. Preclinical studies show that SCF can protect against lethal irradiation, elicit multilineage responses in peripheral blood and bone marrow cellularity, and increase circulating peripheral blood progenitor cells (PBPC) in a dose-dependent manner. Recombinant human SCF has major clinical potential through its synergy with other factors, especially recombinant human granulocyte colony-stimulating factor, to enhance mobilization of PBPC.

Full Text

Duke Authors

Cited Authors

  • Morstyn, G; Brown, S; Gordon, M; Crawford, J; Demetri, G; Rich, W; McGuire, B; Foote, M; McNiece, I

Published Date

  • March 1994

Published In

Volume / Issue

  • 51 / 2

Start / End Page

  • 205 - 214

PubMed ID

  • 7515171

Pubmed Central ID

  • 7515171

International Standard Serial Number (ISSN)

  • 0030-2414

Digital Object Identifier (DOI)

  • 10.1159/000227335

Language

  • eng

Conference Location

  • Switzerland