A xanthine oxidase/colloidal gold enzyme electrode for amperometric biosensor applications


Journal Article

An electrode has been prepared based on xanthine oxidase adsorbed to colloidal gold and evaporated onto the surface of glassy carbon. This electrode responds to xanthine or hypoxanthine in the absence of added mediator by electrochemical oxidation of the enzymatic oxidation product, uric acid, at the electrode surface. The electrode can also be used in the presence of an electron transfer mediator to detect other substrates for xanthine oxidase such as 4-hydroxypyrimidine.

Full Text

Duke Authors

Cited Authors

  • Zhao, J; O'Daly, JP; Henkens, RW; Stonehuerner, J; Crumbliss, AL

Published Date

  • January 1, 1996

Published In

Volume / Issue

  • 11 / 5

Start / End Page

  • 493 - 502

International Standard Serial Number (ISSN)

  • 0956-5663

Digital Object Identifier (DOI)

  • 10.1016/0956-5663(96)86786-8

Citation Source

  • Scopus