Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity.

Journal Article (Journal Article)

Xenotropic murine leukemia virus-related virus (XMRV) is a novel retrovirus, related to murine leukemia virus (MLV), that has been implicated in human disease. If XMRV is indeed able to replicate in humans, then one might predict that XMRV would have developed resistance to human innate antiviral resistance factors such as APOBEC3G (hA3G). In fact, we observed that XMRV and MLV are both highly sensitive to inhibition by hA3G and equally resistant to inhibition by murine APOBEC3. While several human prostate cancer cell lines were found to lack hA3G, stable expression of physiological levels of hA3G rendered these cells refractory to XMRV replication. Few human tissues fail to express hA3G, and we therefore hypothesize that XMRV replicates in one or more hA3G-negative reservoir tissues and/or that human XMRV infections are likely to be rare and potentially of zoonotic origin.

Full Text

Duke Authors

Cited Authors

  • Bogerd, HP; Zhang, F; Bieniasz, PD; Cullen, BR

Published Date

  • February 5, 2011

Published In

Volume / Issue

  • 410 / 1

Start / End Page

  • 234 - 239

PubMed ID

  • 21131013

Pubmed Central ID

  • PMC3035163

Electronic International Standard Serial Number (EISSN)

  • 1096-0341

Digital Object Identifier (DOI)

  • 10.1016/j.virol.2010.11.011


  • eng

Conference Location

  • United States