Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses.


Journal Article

Studies of potent antiretroviral combination regimens were undertaken in young infants to evaluate the potential for long-term suppression of viral replication and to evaluate the immune consequences of such therapies. Early combination antiretroviral therapy led to a loss of plasma viremia, cultivable virus, and labile extrachromosomal replication intermediates. Despite preservation of immune function, persistent human immunodeficiency type 1 (HIV-1)-specific immune responses were not detected in most infants. The absence of detectable, persisting immune responses in most HIV-1-infected infants treated early contrasts with what is typically seen in adults who are treated early. These results are consistent with the notion that early combination antiretroviral therapy of HIV-1-infected infants allows the long-term suppression of viral replication.

Full Text

Duke Authors

Cited Authors

  • Luzuriaga, K; McManus, M; Catalina, M; Mayack, S; Sharkey, M; Stevenson, M; Sullivan, JL

Published Date

  • August 2000

Published In

Volume / Issue

  • 74 / 15

Start / End Page

  • 6984 - 6991

PubMed ID

  • 10888637

Pubmed Central ID

  • 10888637

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.74.15.6984-6991.2000


  • eng

Conference Location

  • United States