Neoadjuvant Chemoradiation for Rectal Cancer


Journal Article

Significant advances have been made in the treatment of rectal cancer patients. Phase III studies have demonstrated the efficacy of neoadjuvant and adjuvant radiation therapy and chemotherapy in improving the outcome of patients with locally advanced disease. Data from the randomized German CAO/ARO/AIO-94 trial of preoperative versus postoperative chemoradiation has established the foundation for the use of preoperative chemoradiation in the treatment of patients with clinical stage II and III rectal cancer. Phase III studies are now examining innovative strategies of chemotherapy and targeted agents with radiation therapy. © 2008 Elsevier Inc. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Willett, CG; Czito, BG

Published Date

  • December 1, 2008

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • 197 - 202

International Standard Serial Number (ISSN)

  • 1043-1489

Digital Object Identifier (DOI)

  • 10.1053/j.scrs.2008.09.003

Citation Source

  • Scopus