Optimal management of malignant pleural effusions (results of CALGB 30102).

Journal Article (Clinical Trial, Phase III;Journal Article;Multicenter Study)

The optimal strategy to achieve palliation of malignant pleural effusions (MPEs) is unknown. This multi-institutional, prospective, randomized trial compares 2 established methods for controlling symptomatic unilateral MPEs. Patients with unilateral MPEs were randomized to either daily tunneled catheter drainage (TCD) or bedside talc pleurodesis (TP). This trial is patterned after a previous randomized trial that showed that bedside TP was equivalent to thoracoscopic TP (CALGB 9334). The primary end point of the current study was combined success: consistent/reliable drainage/pleurodesis, lung expansion, and 30-day survival. A secondary end point, survival with effusion control, was added retrospectively. This trial randomized 57 patients who were similar in terms of age (62 years), active chemotherapy (28%), and histologic diagnosis (lung, 63%; breast, 12%; other/unknown cancers, 25%) to either bedside TP or TCD. Combined success was higher with TCD (62%) than with TP (46%; odds ratio, 5.0; P = .064). Multivariate regression analysis revealed that patients treated with TCD had better 30-day activity without dyspnea scores (8.7 vs. 5.9; P = .036), especially in the subgroup with impaired expansion (9.1 vs. 4.6; P = .042). Patients who underwent TCD had better survival with effusion control at 30 days compared with those who underwent TP (82% vs. 52%, respectively; P = .024). In this prospective randomized trial, TCD achieved superior palliation of unilateral MPEs than TP, particularly in patients with trapped lungs.

Full Text

Duke Authors

Cited Authors

  • Demmy, TL; Gu, L; Burkhalter, JE; Toloza, EM; D'Amico, TA; Sutherland, S; Wang, X; Archer, L; Veit, LJ; Kohman, L; Cancer and Leukemia Group B,

Published Date

  • August 2012

Published In

Volume / Issue

  • 10 / 8

Start / End Page

  • 975 - 982

PubMed ID

  • 22878823

Pubmed Central ID

  • PMC5630261

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2012.0102


  • eng

Conference Location

  • United States