The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement.

Journal Article (Journal Article;Review)

Patients with stage IIIA non-small cell lung cancer, determined based on involvement of ipsilateral mediastinal lymph nodes, represent the most challenging management problem in this disease. Patients with this stage disease may have very different degrees of lymph node involvement. The pathologic confirmation of this involvement is a key step in the therapeutic decision. The difference in the degree of lymph node compromise has prognostic and treatment implications. Based on multiple considerations, patients can be treated with induction chemotherapy, chemoradiotherapy followed by surgery, or definitive chemoradiotherapy without surgery. Data derived from clinical trials have provided incomplete guidance for physicians and their patients. The best therapeutic plan is achieved through the multidisciplinary cooperation of a team specialized in lung cancer.

Full Text

Duke Authors

Cited Authors

  • Martins, RG; D'Amico, TA; Loo, BW; Pinder-Schenck, M; Borghaei, H; Chaft, JE; Ganti, AKP; Kong, F-MS; Kris, MG; Lennes, IT; Wood, DE

Published Date

  • May 2012

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 599 - 613

PubMed ID

  • 22570291

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2012.0062


  • eng

Conference Location

  • United States