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The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement.

Publication ,  Journal Article
Martins, RG; D'Amico, TA; Loo, BW; Pinder-Schenck, M; Borghaei, H; Chaft, JE; Ganti, AKP; Kong, F-MS; Kris, MG; Lennes, IT; Wood, DE
Published in: J Natl Compr Canc Netw
May 2012

Patients with stage IIIA non-small cell lung cancer, determined based on involvement of ipsilateral mediastinal lymph nodes, represent the most challenging management problem in this disease. Patients with this stage disease may have very different degrees of lymph node involvement. The pathologic confirmation of this involvement is a key step in the therapeutic decision. The difference in the degree of lymph node compromise has prognostic and treatment implications. Based on multiple considerations, patients can be treated with induction chemotherapy, chemoradiotherapy followed by surgery, or definitive chemoradiotherapy without surgery. Data derived from clinical trials have provided incomplete guidance for physicians and their patients. The best therapeutic plan is achieved through the multidisciplinary cooperation of a team specialized in lung cancer.

Duke Scholars

Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

May 2012

Volume

10

Issue

5

Start / End Page

599 / 613

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mediastinum
  • Lymphatic Metastasis
  • Lymph Nodes
  • Lung Neoplasms
  • Humans
  • Clinical Trials as Topic
 

Citation

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Martins, R. G., D’Amico, T. A., Loo, B. W., Pinder-Schenck, M., Borghaei, H., Chaft, J. E., … Wood, D. E. (2012). The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement. J Natl Compr Canc Netw, 10(5), 599–613. https://doi.org/10.6004/jnccn.2012.0062
Martins, Renato G., Thomas A. D’Amico, Billy W. Loo, Mary Pinder-Schenck, Hossein Borghaei, Jamie E. Chaft, Apar Kishor P. Ganti, et al. “The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement.J Natl Compr Canc Netw 10, no. 5 (May 2012): 599–613. https://doi.org/10.6004/jnccn.2012.0062.
Martins RG, D’Amico TA, Loo BW, Pinder-Schenck M, Borghaei H, Chaft JE, et al. The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement. J Natl Compr Canc Netw. 2012 May;10(5):599–613.
Martins, Renato G., et al. “The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement.J Natl Compr Canc Netw, vol. 10, no. 5, May 2012, pp. 599–613. Pubmed, doi:10.6004/jnccn.2012.0062.
Martins RG, D’Amico TA, Loo BW, Pinder-Schenck M, Borghaei H, Chaft JE, Ganti AKP, Kong F-MS, Kris MG, Lennes IT, Wood DE. The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement. J Natl Compr Canc Netw. 2012 May;10(5):599–613.

Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

May 2012

Volume

10

Issue

5

Start / End Page

599 / 613

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Randomized Controlled Trials as Topic
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mediastinum
  • Lymphatic Metastasis
  • Lymph Nodes
  • Lung Neoplasms
  • Humans
  • Clinical Trials as Topic