Bayesian estimation of genomic distance.

Journal Article (Journal Article)

We present a Bayesian approach to the problem of inferring the number of inversions and translocations separating two species. The main reason for developing this method is that it will allow us to test hypotheses about the underlying mechanisms, such as the distribution of inversion track lengths or rate constancy among lineages. Here, we apply these methods to comparative maps of eggplant and tomato, human and cat, and human and cattle with 170, 269, and 422 markers, respectively. In the first case the most likely number of events is larger than the parsimony value. In the last two cases the parsimony solutions have very small probability.

Full Text

Duke Authors

Cited Authors

  • Durrett, R; Nielsen, R; York, TL

Published Date

  • January 2004

Published In

Volume / Issue

  • 166 / 1

Start / End Page

  • 621 - 629

PubMed ID

  • 15020449

Pubmed Central ID

  • PMC1470709

Electronic International Standard Serial Number (EISSN)

  • 1943-2631

International Standard Serial Number (ISSN)

  • 0016-6731

Digital Object Identifier (DOI)

  • 10.1534/genetics.166.1.621


  • eng