Approximating selective sweeps.

Published

Journal Article

The fixation of advantageous mutations in a population has the effect of reducing variation in the DNA sequence near that mutation. Kaplan et al. (1989) used a three-phase simulation model to study the effect of selective sweeps on genealogies. However, most subsequent work has simplified their approach by assuming that the number of individuals with the advantageous allele follows the logistic differential equation. We show that the impact of a selective sweep can be accurately approximated by a random partition created by a stick-breaking process. Our simulation results show that ignoring the randomness when the number of individuals with the advantageous allele is small can lead to substantial errors.

Full Text

Duke Authors

Cited Authors

  • Durrett, R; Schweinsberg, J

Published Date

  • September 2004

Published In

Volume / Issue

  • 66 / 2

Start / End Page

  • 129 - 138

PubMed ID

  • 15302222

Pubmed Central ID

  • 15302222

Electronic International Standard Serial Number (EISSN)

  • 1096-0325

International Standard Serial Number (ISSN)

  • 0040-5809

Digital Object Identifier (DOI)

  • 10.1016/j.tpb.2004.04.002

Language

  • eng