Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.
Journal Article (Journal Article)
We use methods of maximum likelihood estimation to fit several microsatellite mutation models to the observed length distribution of dinucletoide repeats in the Drosophila and human genomes. All simple models are rejected by this procedure. Two new models, one with quadratic and another with piecewise linear slippage rates, have the best fits and agree with recent experimental studies by predicting that long microsatellites have a bias toward contractions.
Full Text
Duke Authors
Cited Authors
- Calabrese, P; Durrett, R
Published Date
- May 2003
Published In
Volume / Issue
- 20 / 5
Start / End Page
- 715 - 725
PubMed ID
- 12679531
Pubmed Central ID
- 12679531
Electronic International Standard Serial Number (EISSN)
- 1537-1719
International Standard Serial Number (ISSN)
- 0737-4038
Digital Object Identifier (DOI)
- 10.1093/molbev/msg084
Language
- eng