Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.

Journal Article (Journal Article)

We use methods of maximum likelihood estimation to fit several microsatellite mutation models to the observed length distribution of dinucletoide repeats in the Drosophila and human genomes. All simple models are rejected by this procedure. Two new models, one with quadratic and another with piecewise linear slippage rates, have the best fits and agree with recent experimental studies by predicting that long microsatellites have a bias toward contractions.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Durrett, Richard Timothy

Cited Authors

Calabrese, P; Durrett, R

Published Date

May 2003

Published In

Molecular Biology and Evolution

Volume / Issue

20 / 5

Start / End Page

715 - 725

PubMed ID

12679531

Electronic International Standard Serial Number (EISSN)

1537-1719

International Standard Serial Number (ISSN)

0737-4038

Digital Object Identifier (DOI)

10.1093/molbev/msg084

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