Dinucleotide repeats in the Drosophila and human genomes have complex, length-dependent mutation processes.

Published

Journal Article

We use methods of maximum likelihood estimation to fit several microsatellite mutation models to the observed length distribution of dinucletoide repeats in the Drosophila and human genomes. All simple models are rejected by this procedure. Two new models, one with quadratic and another with piecewise linear slippage rates, have the best fits and agree with recent experimental studies by predicting that long microsatellites have a bias toward contractions.

Full Text

Duke Authors

Cited Authors

  • Calabrese, P; Durrett, R

Published Date

  • May 2003

Published In

Volume / Issue

  • 20 / 5

Start / End Page

  • 715 - 725

PubMed ID

  • 12679531

Pubmed Central ID

  • 12679531

Electronic International Standard Serial Number (EISSN)

  • 1537-1719

International Standard Serial Number (ISSN)

  • 0737-4038

Digital Object Identifier (DOI)

  • 10.1093/molbev/msg084

Language

  • eng