Bayesian estimation of the number of inversions in the history of two chromosomes.

Published

Journal Article

We present a Bayesian approach to the problem of inferring the history of inversions separating homologous chromosomes from two different species. The method is based on Markov Chain Monte Carlo (MCMC) and takes full advantage of all the information from marker order. We apply the method both to simulated data and to two real data sets. For the simulated data, we show that the MCMC method provides accurate estimates of the true posterior distributions and in the analysis of the real data we show that the most likely number of inversions in some cases is considerably larger than estimates obtained based on the parsimony inferred number of inversions. Indeed, in the case of the Drosophila repleta-D. melanogaster comparison, the lower boundary of a 95% highest posterior density credible interval for the number of inversions is considerably larger than the most parsimonious number of inversions.

Full Text

Duke Authors

Cited Authors

  • York, TL; Durrett, R; Nielsen, R

Published Date

  • January 2002

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 805 - 818

PubMed ID

  • 12614548

Pubmed Central ID

  • 12614548

Electronic International Standard Serial Number (EISSN)

  • 1557-8666

International Standard Serial Number (ISSN)

  • 1066-5277

Digital Object Identifier (DOI)

  • 10.1089/10665270260518281

Language

  • eng