The equilibrium distribution for a generalized Sankoff-Ferretti model accurately predicts chromosome size distributions in a wide variety of species


Journal Article

Sankoff and Ferretti (1996) introduced several models of the evolution of chromosome size by reciprocal translocations, where for simplicity they ignored the existence of centromeres. However, when they compared the models to data on six organisms they found that their short chromosomes were too short, and their long chromosomes were too long. Here, we consider a generalization of their proportional model with explicit chromosome centromeres and introduce fitness functions based on recombination probabilities and on the length of the longest chromosome arm. We find a simple formula for the stationary distribution for our model which fits the data on chromosome lengths in many, but not all, species.

Full Text

Duke Authors

Cited Authors

  • Arkendra, DE; Ferguson, M; Sindi, S; Durrett, R

Published Date

  • June 1, 2001

Published In

Volume / Issue

  • 38 / 2

Start / End Page

  • 324 - 334

International Standard Serial Number (ISSN)

  • 0021-9002

Digital Object Identifier (DOI)

  • 10.1239/jap/996986747

Citation Source

  • Scopus