A simple formula useful for positional cloning.

Journal Article (Journal Article)

We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis.

Full Text

Duke Authors

Cited Authors

  • Durrett, RT; Chen, K-Y; Tanksley, SD

Published Date

  • January 2002

Published In

Volume / Issue

  • 160 / 1

Start / End Page

  • 353 - 355

PubMed ID

  • 11805070

Pubmed Central ID

  • PMC1461938

Electronic International Standard Serial Number (EISSN)

  • 1943-2631

International Standard Serial Number (ISSN)

  • 0016-6731

Digital Object Identifier (DOI)

  • 10.1093/genetics/160.1.353

Language

  • eng