Radiation dose-volume effects in the stomach and small bowel.

Published

Journal Article (Review)

Published data suggest that the risk of moderately severe (>or=Grade 3) radiation-induced acute small-bowel toxicity can be predicted with a threshold model whereby for a given dose level, D, if the volume receiving that dose or greater (VD) exceeds a threshold quantity, the risk of toxicity escalates. Estimates of VD depend on the means of structure segmenting (e.g., V15 = 120 cc if individual bowel loops are outlined or V45 = 195 cc if entire peritoneal potential space of bowel is outlined). A similar predictive model of acute toxicity is not available for stomach. Late small-bowel/stomach toxicity is likely related to maximum dose and/or volume threshold parameters qualitatively similar to those related to acute toxicity risk. Concurrent chemotherapy has been associated with a higher risk of acute toxicity, and a history of abdominal surgery has been associated with a higher risk of late toxicity.

Full Text

Duke Authors

Cited Authors

  • Kavanagh, BD; Pan, CC; Dawson, LA; Das, SK; Li, XA; Ten Haken, RK; Miften, M

Published Date

  • March 1, 2010

Published In

Volume / Issue

  • 76 / 3 Suppl

Start / End Page

  • S101 - S107

PubMed ID

  • 20171503

Pubmed Central ID

  • 20171503

Electronic International Standard Serial Number (EISSN)

  • 1879-355X

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2009.05.071

Language

  • eng

Conference Location

  • United States