Radiation-associated kidney injury.
Journal Article (Journal Article;Review)
The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation. The incidence of radiotherapy-associated kidney injury is likely underreported owing to its long latency and because the toxicity is often attributed to more common causes of kidney injury. The pathophysiology of radiation injury is poorly understood. Its presentation can be acute and irreversible or subtle, with a gradual progressive dysfunction over years. A variety of dose and volume parameters have been associated with renal toxicity and are reviewed to provide treatment guidelines. The available predictive models are suboptimal and require validation. Mitigation of radiation nephropathy with angiotensin-converting enzyme inhibitors and other compounds has been shown in animal models and, more recently, in patients.
Full Text
Duke Authors
Cited Authors
- Dawson, LA; Kavanagh, BD; Paulino, AC; Das, SK; Miften, M; Li, XA; Pan, C; Ten Haken, RK; Schultheiss, TE
Published Date
- March 1, 2010
Published In
Volume / Issue
- 76 / 3 Suppl
Start / End Page
- S108 - S115
PubMed ID
- 20171504
Electronic International Standard Serial Number (EISSN)
- 1879-355X
Digital Object Identifier (DOI)
- 10.1016/j.ijrobp.2009.02.089
Language
- eng
Conference Location
- United States