Radiation-associated kidney injury.

Published

Journal Article (Review)

The kidneys are the dose-limiting organs for radiotherapy to upper abdominal cancers and during total body irradiation. The incidence of radiotherapy-associated kidney injury is likely underreported owing to its long latency and because the toxicity is often attributed to more common causes of kidney injury. The pathophysiology of radiation injury is poorly understood. Its presentation can be acute and irreversible or subtle, with a gradual progressive dysfunction over years. A variety of dose and volume parameters have been associated with renal toxicity and are reviewed to provide treatment guidelines. The available predictive models are suboptimal and require validation. Mitigation of radiation nephropathy with angiotensin-converting enzyme inhibitors and other compounds has been shown in animal models and, more recently, in patients.

Full Text

Duke Authors

Cited Authors

  • Dawson, LA; Kavanagh, BD; Paulino, AC; Das, SK; Miften, M; Li, XA; Pan, C; Ten Haken, RK; Schultheiss, TE

Published Date

  • March 1, 2010

Published In

Volume / Issue

  • 76 / 3 Suppl

Start / End Page

  • S108 - S115

PubMed ID

  • 20171504

Pubmed Central ID

  • 20171504

Electronic International Standard Serial Number (EISSN)

  • 1879-355X

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2009.02.089

Language

  • eng

Conference Location

  • United States