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The utility of non-axial treatment beam orientations for lower lobe lung cancers.

Publication ,  Journal Article
Quaranta, BP; Das, SK; Shafman, TD; Light, KL; Marks, LB
Published in: J Appl Clin Med Phys
January 28, 2010

Traditional treatment beams for non-small-cell lung cancer are limited to the axial plane. For many tumor geometries, non-axial orientations appear to reduce the dose to normal tissues (e.g. heart, liver). We hypothesize that non-axial beams provide a significant reduction in incidental irradiation of the heart and liver, while maintaining adequate target coverage. CT scans of twenty-four patients with lower lobe lung cancers were studied. For each patient, an opposed oblique axial beam pair and a competing non-axial opposed oblique pair were generated, both off-cord. The competing plans delivered comparable doses/margins to the GTV. DVHs and integral doses were computed for all structures of interest for the two competing plans. The integral dose was compared for axial and non-axial beams for each contoured organ using a paired t-test. Dose to the heart was significantly lower for the non-axial plans ( p = .0001). For 20/24 patients, the integral heart dose was reduced by using non-axial beams. In those patients with tumors located in the inferior right lower lobe, a lower dose to the liver was achieved when non-axial beams were used. There were no meaningful differences in dose to the GTV, lungs, or skin between axial and non-axial beams. Non-axial beams can reduce the dose to the heart and liver in patients with lower lobe lung cancers. Non-axial beams may be clinically beneficial in these patients and should be considered as an option during planning.

Duke Scholars

Published In

J Appl Clin Med Phys

DOI

EISSN

1526-9914

Publication Date

January 28, 2010

Volume

11

Issue

1

Start / End Page

3010

Location

United States

Related Subject Headings

  • Spinal Cord
  • Skin
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiation Injuries
  • Nuclear Medicine & Medical Imaging
  • Lung Neoplasms
  • Lung
  • Liver
  • Imaging, Three-Dimensional
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Quaranta, B. P., Das, S. K., Shafman, T. D., Light, K. L., & Marks, L. B. (2010). The utility of non-axial treatment beam orientations for lower lobe lung cancers. J Appl Clin Med Phys, 11(1), 3010. https://doi.org/10.1120/jacmp.v11i1.3010
Quaranta, Brian P., Shiva K. Das, Timothy D. Shafman, Kim L. Light, and Lawrence B. Marks. “The utility of non-axial treatment beam orientations for lower lobe lung cancers.J Appl Clin Med Phys 11, no. 1 (January 28, 2010): 3010. https://doi.org/10.1120/jacmp.v11i1.3010.
Quaranta BP, Das SK, Shafman TD, Light KL, Marks LB. The utility of non-axial treatment beam orientations for lower lobe lung cancers. J Appl Clin Med Phys. 2010 Jan 28;11(1):3010.
Quaranta, Brian P., et al. “The utility of non-axial treatment beam orientations for lower lobe lung cancers.J Appl Clin Med Phys, vol. 11, no. 1, Jan. 2010, p. 3010. Pubmed, doi:10.1120/jacmp.v11i1.3010.
Quaranta BP, Das SK, Shafman TD, Light KL, Marks LB. The utility of non-axial treatment beam orientations for lower lobe lung cancers. J Appl Clin Med Phys. 2010 Jan 28;11(1):3010.

Published In

J Appl Clin Med Phys

DOI

EISSN

1526-9914

Publication Date

January 28, 2010

Volume

11

Issue

1

Start / End Page

3010

Location

United States

Related Subject Headings

  • Spinal Cord
  • Skin
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiation Injuries
  • Nuclear Medicine & Medical Imaging
  • Lung Neoplasms
  • Lung
  • Liver
  • Imaging, Three-Dimensional