The utility of non-axial treatment beam orientations for lower lobe lung cancers.
Traditional treatment beams for non-small-cell lung cancer are limited to the axial plane. For many tumor geometries, non-axial orientations appear to reduce the dose to normal tissues (e.g. heart, liver). We hypothesize that non-axial beams provide a significant reduction in incidental irradiation of the heart and liver, while maintaining adequate target coverage. CT scans of twenty-four patients with lower lobe lung cancers were studied. For each patient, an opposed oblique axial beam pair and a competing non-axial opposed oblique pair were generated, both off-cord. The competing plans delivered comparable doses/margins to the GTV. DVHs and integral doses were computed for all structures of interest for the two competing plans. The integral dose was compared for axial and non-axial beams for each contoured organ using a paired t-test. Dose to the heart was significantly lower for the non-axial plans ( p = .0001). For 20/24 patients, the integral heart dose was reduced by using non-axial beams. In those patients with tumors located in the inferior right lower lobe, a lower dose to the liver was achieved when non-axial beams were used. There were no meaningful differences in dose to the GTV, lungs, or skin between axial and non-axial beams. Non-axial beams can reduce the dose to the heart and liver in patients with lower lobe lung cancers. Non-axial beams may be clinically beneficial in these patients and should be considered as an option during planning.
Duke Scholars
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Related Subject Headings
- Spinal Cord
- Skin
- Radiotherapy Planning, Computer-Assisted
- Radiotherapy Dosage
- Radiation Injuries
- Nuclear Medicine & Medical Imaging
- Lung Neoplasms
- Lung
- Liver
- Imaging, Three-Dimensional
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Spinal Cord
- Skin
- Radiotherapy Planning, Computer-Assisted
- Radiotherapy Dosage
- Radiation Injuries
- Nuclear Medicine & Medical Imaging
- Lung Neoplasms
- Lung
- Liver
- Imaging, Three-Dimensional